ArticleThe journal of allergy and clinical immunology. In practice2025
Prevalence and Potential Risk Factors for T2-Low Asthma Among School-Aged Children in the National Health and Nutrition Examination Survey, 2007-2012.
Article in The journal of allergy and clinical immunology. In practice, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
4 citing papers in PubMed.
- Type 2-low Asthma: Epidemiology, Multiomics, and Emerging Therapies.Current allergy and asthma reports · 2026Review
- Persistent exposure to second-hand smoke and asthma endotypes in a study of Puerto Rican youth.Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology · 2026Article
- Overweight, obesity, adiposity measures, and asthma endotypes in Puerto Rican youth.American journal of respiratory and critical care medicine · 2026Article
- Beyond the Usual Suspects: Unmasking Low-T2 Asthma in Children.Journal of clinical medicine · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
Abstract
backgroundT-helper 2 (T2)-high asthma has been assumed to be the most common asthma endotype in school-aged youth.
objectiveTo assess the prevalence and potential risk factors for T2-low asthma in a representative sample of U.S. children.
methodsCross-sectional study of 4,284 children aged 6 to 17 years in the 2007-2012 National Health and Nutrition Examination Survey (NHANES). Using available biomarkers, T2-low asthma was defined by an absolute peripheral blood eosinophil count (AEC) lower than 300 cells/μL, and fractional exhaled nitric oxide (FeNO) less than 25 ppb; T2-high asthma was defined by AEC of 300 cells/μL or greater or FeNO 25 ppb or greater. In a secondary analysis, an AEC lower than 428 cells/μL and a FeNO lower than 32.5 ppb was used to define T2-low asthma. Multinomial logistic or linear regression was used for the multivariable analysis.
resultsAmong 505 children with asthma, 231 (45.7%) had T2-low asthma. Compared with controls, those with T2-low asthma were 1.1- to 2.1-times significantly more likely to be older, female, and overweight or obese. Children with T2-high asthma were more likely than controls to be male and non-Hispanic Black and to have vitamin D insufficiency and bronchodilator responsiveness. Children with either asthma subtype were more likely than controls to have a family history of asthma, hay fever episodes in the prior year, and lower %predicted forced expiratory volume in 1 second (FEV
conclusionsOverweight was associated with T2-low asthma, whereas non-Hispanic Black race and vitamin D insufficiency were associated with T2-high asthma in this study of U.S. children.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.