Trial reportChest2025
Oxygen Saturation Targets and Neurologic Outcomes Following Cardiac Arrest: A Secondary Analysis of the Pragmatic Investigation of Optimal Oxygen Targets Trial.
Trial report in Chest, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
3 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Conservative Oxygen Targets in Mechanically Ventilated Patients (OXY-BREATHES): A Systematic Review and Meta-Analysis of Randomized Controlled Trials.Critical care medicine · 2026Pooled it
- A logical interpretation of the data on optimal oxygen therapy targets for unresponsive adults in ICU after cardiac arrest.Critical care and resuscitation : journal of the Australasian Academy of Critical Care Medicine · 2026Article
- Temporal dimensions of oxygen saturation exposure and clinical outcomes in critically ill patients: a retrospective multi-database cohort study.Critical care (London, England) · 2025Article
Corrections and comments
- Update of
Authors and funding
16 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundMore than 600,000 adults in the United States experience an out-of-hospital or in-hospital cardiac arrest each year. Following resuscitation from cardiac arrest, most patients receive mechanical ventilation. The oxygenation target that optimizes neurologic outcomes following cardiac arrest is uncertain. RESEARCH QUESTION: Following cardiac arrest, does a lower oxygen saturation (Spo STUDY DESIGN AND
methodsThis study was a secondary analysis of patients who experienced a cardiac arrest prior to enrollment in the Pragmatic Investigation of Optimal Oxygen Targets (PILOT) trial. The PILOT trial assigned critically ill adults receiving mechanical ventilation to a lower (88%-92%), intermediate (92%-96%), or higher (96%-100%) Spo
resultsOf 2,987 patients in the PILOT trial, 339 (11.3%) experienced a cardiac arrest prior to enrollment: 221 were assigned to a lower or intermediate Spo
interpretationAmong patients receiving mechanical ventilation following a cardiac arrest, use of a lower or intermediate Spo
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.