ArticleGastroenterology2025
Inadequate Propulsion and Pelvic Floor Relaxation in Dyssynergic Defecation: Insights From Synchronous Proctomanometry.
Article in Gastroenterology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- Thickening of the internal anal sphincter: correlation with external rectal intussusception and associated features at MR proctography and anal manometry.Abdominal radiology (New York) · 2026Article
- Integrating technologies for comprehensive anorectal assessment: steps toward objective functional diagnosis.Frontiers in medicine · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
Abstract
BACKGROUND &
aimsHigh-resolution anorectal manometry (HR-ARM) and fluoroscopic defecography, which are used to diagnose dyssynergic defecation (DD), are performed asynchronously and in different positions. This limits our understanding of the relationship between anorectal pressures and rectal evacuation and the diagnostic utility of HR-ARM. We aimed to assess anorectal pressures in isolation and synchronously with defecography.
methodsWe evaluated anorectal pressures during evacuation with left lateral HR-ARM, seated HR-ARM, and seated, concurrent fluoroscopic barium proctography/manometry (proctomanometry). Rectal evacuation was assessed with proctomanometry and rectal balloon expulsion time (BET).
resultsForty-two (86%) of 49 healthy (22 women) vs 25 of 55 (45%) constipated participants (28 women) evacuated ≥25% barium ("evacuators") (P < .001). During the preparatory phase of defecation, rectal and anal pressures increased concurrently; anorectal descent followed. During evacuation, the anal canal opened and evacuation occurred. During preparatory and evacuation phases, rectal pressure, anorectal descent, and widening of anorectal angle independently predicted evacuation (P < .05). During evacuation, the rectoanal gradient was (1) lower in participants with a prolonged BET and/or reduced rectal evacuation (P ≤ .001) and (2) greatest with proctomanometry, lower during seated HR-ARM, and lowest during left lateral HR-ARM (P < .001). Four clusters based on pressure and motion were associated with evacuator status and BET (P < .001).
conclusionsEarly events-increased rectal pressure (propulsive force), anorectal angle (puborectalis relaxation), and anorectal descent (perineal relaxation)-determine evacuation. Body position and rectal filling affect the rectoanal gradient. Most DD patients have both impaired propulsion and relaxation. Constipated patients with a prolonged BET and/or reduced evacuation have DD.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.