Evidence map›Paper›PMID 40315838›Full record

ArticleCell host & microbe2025

An engineered gut bacterium protects against dietary methylmercury exposure in pregnant mice.

Kristie B Yu, Franciscus Chandra, Elena J Coley-O'Rourke, Erik T Paulson, Anna Novoselov, David Zhang, Delanie Finnigan, Jorge Paramo, Arlene Lopez-Romero, Tien S Dong and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell host & microbe, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Review
  2. Review
  3. Article
  4. Review
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Kristie B YuDepartment of Integrative Biology and Physiology, University of California, Los Angeles, Los Angeles, CA 90095, USA.
Franciscus ChandraDepartment of Integrative Biology and Physiology, University of California, Los Angeles, Los Angeles, CA 90095, USA.
Elena J Coley-O'RourkeDepartment of Integrative Biology and Physiology, University of California, Los Angeles, Los Angeles, CA 90095, USA.
Erik T PaulsonScripps Institution of Oceanography, University of California, San Diego, La Jolla, CA 92037, USA.
Anna NovoselovDepartment of Integrative Biology and Physiology, University of California, Los Angeles, Los Angeles, CA 90095, USA.
David ZhangUCLA Goodman-Luskin Microbiome Center, Vatche and Tamar Manoukian Division of Digestive Diseases, Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA 90095, USA.
Delanie FinniganDepartment of Integrative Biology and Physiology, University of California, Los Angeles, Los Angeles, CA 90095, USA.
Jorge ParamoDepartment of Integrative Biology and Physiology, University of California, Los Angeles, Los Angeles, CA 90095, USA.
Arlene Lopez-RomeroDepartment of Integrative Biology and Physiology, University of California, Los Angeles, Los Angeles, CA 90095, USA.
Tien S DongUCLA Goodman-Luskin Microbiome Center, Vatche and Tamar Manoukian Division of Digestive Diseases, Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA 90095, USA.
Amina T SchartupScripps Institution of Oceanography, University of California, San Diego, La Jolla, CA 92037, USA. Electronic address: aschartup@ucsd.edu.
Elaine Y HsiaoDepartment of Integrative Biology and Physiology, University of California, Los Angeles, Los Angeles, CA 90095, USA; UCLA Goodman-Luskin Microbiome Center, Vatche and Tamar Manoukian Division of Digestive Diseases, Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA 90095, USA. Electronic address: ehsiao@g.ucla.edu.

Funding

UCLA-Caltech Medical Scientist Training ProgramT32GM152342 · NIGMS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI Olujimi A Ajijola, David Wayne Dawson · 2024 to 2026
$5.3M
Scripps Center for Oceans and Human Health: advancing the science of marine contaminants and seafood securityP01ES035541 · NIEHS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI AMRO M HAMDOUN, BRADLEY S MOORE · 2024 to 2026
$2.4M
Uncovering Microbial Modifiers of Antidepressant Responses during PregnancyR01HD111079 · NICHD · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI Elaine Hsiao · 2023 to 2026
$2.0M
NICHD NIH HHS R01 HD111079NIEHS NIH HHS P01 ES035541NIGMS NIH HHS T32 GM152342
6 · The paper itself

Abstract

Despite efforts to decrease mercury emissions, chronic exposure to the neurotoxicant methylmercury (MeHg) continues to be a global problem that contributes to disparities in risk for neurological and metabolic diseases. Herein we engineer a human commensal gut bacterium, Bacteroides thetaiotaomicron (Bt), to detoxify MeHg by heterologous expression of organomercury lyase (MerB) and mercuric reductase (MerA) genes derived from a resistant bacterium isolated from Hg-polluted mines. We demonstrate that Bt

Indexed as

Dietary ExposureGastrointestinal MicrobiomeMethylmercury CompoundsAnimalsBrainFemaleHumansLiverLyasesMiceOxidoreductasesPlacentaPregnancyLyasesmercuric reductaseMethylmercury CompoundsOxidoreductasesBacteroides thetaiotaomicronexposuresmethylmercurymicrobiomeneurodevelopmentneurotoxicantpregnancysynthetic biology

Identifiers

PMID40315838
PMCPMC12086009

What OpenQuestion holds

Textmetadata
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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.