Evidence map›Paper›PMID 40315798›Full record

Observational studyClinics (Sao Paulo, Brazil)2025

Can elastography predict early allograft dysfunction or loss after liver transplantation? A prospective study of diagnostic accuracy.

Guilherme Marques Andrade, Luiz Marcelo Sá Malbouisson, Denise Paranaguá Vezozzo, Wellington Andraus, Paula Sepulveda Mesquita, Luiz Augusto Carneiro D'Albuquerque, Alberto Queiroz Farias, Flair José Carrilho

Abstract readObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in Clinics (Sao Paulo, Brazil), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

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0cells of the map it votes in
1citing papers in PubMed
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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

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5 · Who and what money

Authors and funding

8 authors.

Guilherme Marques AndradeDepartment of Gastroenterology, Faculdade de Medicina da Universidade de São Paulo (FMUSP), São Paulo, SP, Brazil.
Luiz Marcelo Sá MalbouissonDepartment of Gastroenterology, Faculdade de Medicina da Universidade de São Paulo (FMUSP), São Paulo, SP, Brazil; Division of Anesthesiology, Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo (HCFMUSP), São Paulo, SP, Brazil.
Denise Paranaguá VezozzoDepartment of Gastroenterology, Faculdade de Medicina da Universidade de São Paulo (FMUSP), São Paulo, SP, Brazil.
Wellington AndrausDepartment of Gastroenterology, Faculdade de Medicina da Universidade de São Paulo (FMUSP), São Paulo, SP, Brazil.
Paula Sepulveda MesquitaDepartment of Gastroenterology, Faculdade de Medicina da Universidade de São Paulo (FMUSP), São Paulo, SP, Brazil.
Luiz Augusto Carneiro D'AlbuquerqueDepartment of Gastroenterology, Faculdade de Medicina da Universidade de São Paulo (FMUSP), São Paulo, SP, Brazil.
Alberto Queiroz FariasDepartment of Gastroenterology, Faculdade de Medicina da Universidade de São Paulo (FMUSP), São Paulo, SP, Brazil. Electronic address: alberto.farias@hc.fm.usp.br.
Flair José CarrilhoDepartment of Gastroenterology, Faculdade de Medicina da Universidade de São Paulo (FMUSP), São Paulo, SP, Brazil.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionThe imbalance between the demand for liver transplants and the shortage of donors can be addressed by expanding the donor pool, including using extended criteria donors. This strategy may reduce waiting time and list mortality but can increase poor graft function rates, affecting short-term outcomes. Tools to predict and diagnose Early Allograft Dysfunction (EAD) are crucial. Elastography for Liver Stiffness Measurement (LSM) may predict EAD and graft loss early post-transplant.

methodsIn this prospective observational study, the authors assessed the diagnostic accuracy of elastography for predicting EAD or loss in liver transplant recipients admitted to the ICU of Hospital das Clínicas, Universidade de São Paulo, from 2016 to 2018. Patients underwent daily LSM from ICU admission to day 7 post-transplant. EAD was defined by Olthoff et al.'s criteria, and allograft loss was defined by the need for retransplantation or death within 180 days.

resultsEAD developed in 27 patients (44.3 %). The median LSM was 2.12 m/s (IQR 1.87-2.67 m/s) for the EAD group and 1.70 m/s (IQR 1.55-1.90 m/s) for the non-EAD group. For predicting EAD, elastography on day 1 had a c-statistic of 0.83, sensitivity 41 %, specificity 97 %, and accuracy 83 % at a cutoff of 2.39 m/s. For predicting early allograft loss, the c-statistic was 0.93, with a sensitivity 76 %, specificity 100 %, and accuracy 93 % at a cutoff of 2.25 m/s on day 1.

conclusionElastography demonstrated robust performance in predicting EAD and early graft loss post-transplant, outperforming traditional prognostic scores. Further multicenter studies are needed to confirm these findings.

Indexed as

AllograftsElasticity Imaging TechniquesLiver TransplantationPrimary Graft DysfunctionAdultFemaleHumansLiverMaleMiddle AgedPredictive Value of TestsProspective StudiesReproducibility of ResultsSensitivity and SpecificityTime FactorsAllograft lossEarly allograft dysfunctionLiver elastographyLiver transplantation, Graft dysfunction

Identifiers

PMID40315798
PMCPMC12090290

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.