Evidence map›Paper›PMID 40315751›Full record

ArticleJournal of psychiatric research2025

Exploring the effects of cognitive behavioral therapy on cognitive control circuit and behavioral task performance in hoarding disorder.

Paula A Muñoz Rodríguez, Adam Pines, Xue Zhang, Peter J van Roessel, Pavithra Mukunda, Elizabeth McCarthy, Leanne M Williams, Carolyn I Rodríguez

Abstract read
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In one paragraph

Article in Journal of psychiatric research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

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5 · Who and what money

Authors and funding

8 authors.

Paula A Muñoz RodríguezDepartment of Neuroscience, Stanford University, Stanford, CA, USA; Department of Psychiatry and Behavioral Sciences, Stanford University, Stanford, CA, USA.
Adam PinesDepartment of Psychiatry and Behavioral Sciences, Stanford University, Stanford, CA, USA.
Xue ZhangDepartment of Psychiatry and Behavioral Sciences, Stanford University, Stanford, CA, USA.
Peter J van RoesselDepartment of Psychiatry and Behavioral Sciences, Stanford University, Stanford, CA, USA.
Pavithra MukundaDepartment of Psychiatry and Behavioral Sciences, Stanford University, Stanford, CA, USA.
Elizabeth McCarthyDepartment of Psychiatry and Behavioral Sciences, Stanford University, Stanford, CA, USA.
Leanne M WilliamsDepartment of Psychiatry and Behavioral Sciences, Stanford University, Stanford, CA, USA.
Carolyn I RodríguezDepartment of Psychiatry and Behavioral Sciences, Stanford University, Stanford, CA, USA; Veterans Affairs Palo Alto Health Care System, Palo Alto, CA, USA. Electronic address: carolynrodriguez@stanford.edu.

Funding

Training Program in Basic NeuroscienceT32MH020016 · NIMH · STANFORD UNIVERSITY · PI Justin L Gardner, Merritt C Maduke · 1997 to 2026
$16.2M
NIMH NIH HHS T32 MH020016
6 · The paper itself

Abstract

Hoarding disorder (HD) is characterized by difficulty discarding or parting with possessions and clutter, which causes distress or impairment in important areas of functioning. Cognitive behavioral therapy (CBT) for HD has shown promise; however, little is known about the brain mechanisms underlying symptom reduction. We previously reported the robust clinical effects of the Buried in Treasures workshop (BIT)-a skills-based group which incorporates CBT principles-augmented with uncluttering home visits (BIT+), in a waitlist-controlled trial involving adults with HD. This study examined neural activity within a network of regions associated with cognitive control in a subset of HD participants (n = 19) before and after 18 weeks of BIT+ sessions using task-based fMRI during a response inhibition task. We used a comparison group of healthy controls (HC; n = 49). Our behavioral results show that participants in the HD group made more errors of omission while performing the task but did not differ from HCs in their errors of commission. The neuroimaging findings indicated a correlation between improvements in hoarding symptoms and blood-oxygen-level-dependent (BOLD) signal during errors of commission in the right insula and anterior cingulate cortex of post-treatment HD participants, suggesting that changes in this region may be associated with the effectiveness of BIT+ treatment. This is the first study exploring neural activity changes associated with symptom-neutral inhibitory control before and after BIT+ treatment in a HD population.

Indexed as

BrainCognitive Behavioral TherapyHoarding DisorderAdultAgedBrain MappingFemaleHumansInhibition, PsychologicalMagnetic Resonance ImagingMaleMiddle AgedNeuropsychological TestsOxygenOxygenCognitive behavioral therapyCognitive controlfMRIGoNoGoHoarding disorder

Identifiers

PMID40315751
PMCPMC12173174

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.