Evidence map›Paper›PMID 40315404›Full record

ArticleACS nano2025

Nicotinamide Adenine Dinucleotide-Loaded Lubricated Hydrogel Microspheres with a Three-Pronged Approach Alleviate Age-Related Osteoarthritis.

Yanpeng Lin, Hangtian Wu, Jun Wang, Wanling He, Jiahui Hou, Vidmi Taolam Martin, Chencheng Zhu, Yupeng Chen, Junyuan Zhong, Bin Yu and 4 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in ACS nano, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed.

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  3. A sustained NADBioactive materials · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Yanpeng LinDepartment of Radiology, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong 510515, P. R. China.
Hangtian WuDivision of Orthopaedics and Traumatology, Department of Orthopaedics, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong 510515, P. R. China.
Jun WangSchool of Animal Science and Technology, Foshan University, Foshan, Guangdong 528231, People's Republic of China.
Wanling HeDepartment of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Southern Medical University, Guangzhou 510515, P. R. China.
Jiahui HouDivision of Orthopaedics and Traumatology, Department of Orthopaedics, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong 510515, P. R. China.
Vidmi Taolam MartinDivision of Orthopaedics and Traumatology, Department of Orthopaedics, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong 510515, P. R. China.
Chencheng ZhuDivision of Orthopaedics and Traumatology, Department of Orthopaedics, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong 510515, P. R. China.
Yupeng ChenDepartment of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Southern Medical University, Guangzhou 510515, P. R. China.
Junyuan ZhongDepartment of Medical Imaging, Ganzhou People's Hospital, Ganzhou, Jiangxi 341000, P. R. China.
Bin YuDivision of Orthopaedics and Traumatology, Department of Orthopaedics, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong 510515, P. R. China.
Aiping LuInstitute of Integrated Bioinformedicine and Translational Science, Hong Kong Baptist University, Hong Kong 999077, P. R. China.
Daogang GuanDepartment of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Southern Medical University, Guangzhou 510515, P. R. China.
Genggeng QinDepartment of Radiology, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong 510515, P. R. China.
Weiguo ChenDepartment of Radiology, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong 510515, P. R. China.ORCID 0000-0003-1552-0511

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Chondrocyte senescence, synovitis, and decreased level of lubrication play pivotal roles in the pathogenesis of age-related osteoarthritis (AROA). However, there are currently no effective therapeutic interventions capable of altering the progression of OA until it reaches advanced stages, necessitating joint replacement. In this study, lubricious and drug-loaded hydrogel microspheres were designed and fabricated by utilizing microfluidic technology for radical polymerization of chondroitin sulfate methacrylate and incorporating nicotinamide adenine dinucleotide (NAD)-loaded liposomes modified with lactoferrin that are positively charged. Mechanical, tribological, and drug release analyses demonstrated enhanced lubrication properties and an extended drug dissemination time for the NAD@NPs@HM microspheres.

Indexed as

HydrogelsMicrospheresNADOsteoarthritisAgingAnimalsChondrocytesDrug LiberationHumansMaleMiceMice, Inbred C57BLParticle SizeHydrogelsNADage-related osteoarthritiscellular senescencelubricationmacrophage reprogrammingnicotinamide adenine dinucleotide

Identifiers

PMID40315404
PMCPMC12080321

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.