Evidence map›Paper›PMID 40315331›Full record

ArticleScience advances2025

UFMylation orchestrates spatiotemporal coordination of RQC at the ER.

Ivan Penchev, Samantha Gumbin, Francesco Scavone, Otto Berninghausen, Thomas Becker, Ron Kopito, Roland Beckmann

Abstract read
In one paragraph

Article in Science advances, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

  1. Review
  2. The mechanistic basis and cellular functions of UFMylation.Nature reviews. Molecular cell biology · 2026
    Review
  3. Article
  4. Article
  5. Article
  6. Ribosome-associated quality control and related mechanisms.Nature structural & molecular biology · 2026
    Review
  7. Review
  8. Quality control and signaling pathways at stalled ribosomes.Experimental & molecular medicine · 2026
    Review
  9. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Ivan PenchevDepartment of Biochemistry, Gene Center, Feodor-Lynen-Str. 25, University of Munich, 81377, Munich, Germany.ORCID 0009-0003-2611-5367
Samantha GumbinDepartment of Biology, Stanford University, Stanford, CA 94305, USA.ORCID 0000-0002-0257-509X
Francesco ScavoneDepartment of Biology, Stanford University, Stanford, CA 94305, USA.ORCID 0000-0003-3560-7120
Otto BerninghausenDepartment of Biochemistry, Gene Center, Feodor-Lynen-Str. 25, University of Munich, 81377, Munich, Germany.ORCID 0000-0002-9255-0522
Thomas BeckerDepartment of Biochemistry, Gene Center, Feodor-Lynen-Str. 25, University of Munich, 81377, Munich, Germany.ORCID 0000-0001-8458-2738
Ron KopitoDepartment of Biology, Stanford University, Stanford, CA 94305, USA.ORCID 0000-0001-5027-6935
Roland BeckmannDepartment of Biochemistry, Gene Center, Feodor-Lynen-Str. 25, University of Munich, 81377, Munich, Germany.ORCID 0000-0003-4291-3898

Funding

The Ubiquitin Proteasome System in Quality ControlR01GM074874 · NIGMS · STANFORD UNIVERSITY · PI KOPITO, RON R · 2006 to 2022
$8.0M
The role of UFMylation in ribosome quality control at the ERR01GM148477 · NIGMS · STANFORD UNIVERSITY · PI RON R KOPITO · 2023 to 2026
$2.4M
NIGMS NIH HHS R01 GM074874NIGMS NIH HHS R01 GM148477
6 · The paper itself

Abstract

Degradation of arrest peptides from endoplasmic reticulum (ER) translocon-bound 60

Indexed as

Endoplasmic ReticulumRibosome Subunits, Large, EukaryoticHumansProtein BindingProteolysisRibosomal ProteinsRibosomesUbiquitin-Protein LigasesRibosomal ProteinsUbiquitin-Protein Ligases

Identifiers

PMID40315331
PMCPMC12047416

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.