Evidence map›Paper›PMID 40315279›Full record

ArticlePloS one2025

Implementation and evaluation of the 3 Wishes Project in safety-net hospitals: Protocol for a hybrid effectiveness-implementation study.

Thanh H Neville, Anne Walling, Neil S Wenger, Brian S Mittman, Chi-Hong Tseng, Dong Chang, Deborah Cook, Carolyn Jennifer Marentes Ruiz, Hope Cassano, Emily Beers and 4 more

Registry-linked trialAbstract readClinical Trial Protocol
In one paragraph

Article in PloS one, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06277310 (Personalized End of Life Care in Safety-Net Hospitals), which is not on this map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06277310 naactive not recruitingnot on this map

Personalized End of Life Care in Safety-Net Hospitals: Implementation of the 3 Wishes Project

TypeinterventionalSponsorUniversity of California, Los AngelesRan2024 to 2028Enrolled900ConditionsEnd of LifeArms3 Wishes Project
3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Thanh H NevilleDavid Geffen School of Medicine at UCLA, Los Angeles, California, United States of America.ORCID https://orcid.org/0000-0002-8506-7591
Anne WallingDavid Geffen School of Medicine at UCLA, Los Angeles, California, United States of America.
Neil S WengerDavid Geffen School of Medicine at UCLA, Los Angeles, California, United States of America.
Brian S MittmanDepartment of Research and Evaluation, Kaiser Permanente, Oakland, California, United States of America.
Chi-Hong TsengDavid Geffen School of Medicine at UCLA, Los Angeles, California, United States of America.
Dong ChangLos Angeles General Medical Center, Los Angeles, California, United States of America.
Deborah CookDepartments of Medicine, Clinical Epidemiology and Biostatistics, McMaster University, Hamilton, Ontario, Canada.
Carolyn Jennifer Marentes RuizDavid Geffen School of Medicine at UCLA, Los Angeles, California, United States of America.
Hope CassanoHarbor-UCLA Medical Center, Torrance, California, United States of America.
Emily BeersLos Angeles General Medical Center, Los Angeles, California, United States of America.
Rucha GadgilLos Angeles General Medical Center, Los Angeles, California, United States of America.
Nader KamangarOlive View-UCLA Medical Center, Los Angeles, California, United States of America.ORCID https://orcid.org/0000-0002-9206-4954
Nancy BlakeLos Angeles General Medical Center, Los Angeles, California, United States of America.
Derjung M TarnDavid Geffen School of Medicine at UCLA, Los Angeles, California, United States of America.

Funding

Personalized End of Life Care in Safety-Net hospitals: Implementation of the 3 Wishes ProjectR01NR020773 · NINR · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI THANH H NEVILLE · 2023 to 2026
$2.2M
NINR NIH HHS R01 NR020773
6 · The paper itself

Abstract

backgroundPalliative care interventions in the intensive care unit have been shown to improve communication and the quality of death and dying. However, few interventions have been implemented in safety-net hospitals (SNHs), which provide healthcare to low income and uninsured patients. The 3 Wishes Project (3WP) is a low-cost intervention that aims to enhance compassionate end-of-life (EOL) experiences by empowering the clinical team to elicit and fulfill small wishes for patients who are dying in the ICU.

objectiveTo implement and evaluate the 3WP in three SNHs in Los Angeles.

methodsWe conduct a pragmatic cluster-randomized stepped wedge type 2 hybrid effectiveness-implementation study to implement and evaluate the effect of the 3WP (compared to usual care) on quality of EOL ICU care, bereaved families' psychological symptoms, and clinician burnout. Prior to implementation, interviews with stakeholders from each hospital will refine the implementation strategy. Starting 6-10 months prior to 3WP implementation at each site and continuing throughout the study, we will survey bereaved families once 3 months after each patient's death. Surveys will query: EOL care, anxiety, depression, and post-traumatic stress disorder (PTSD). Each SNH ICU starts the 3WP at a randomly assigned time that is staggered by 2 months. Nurses are surveyed on burnout before implementation, 6 months, and 12 months after 3WP implementation. Semi-structured interviews are conducted with 10-12 family members per SNH who received 3WP and 10-12 nurses per SNH a year after implementation. We will use the RE-AIM (Reach, Effectiveness, Adoption, Implementation, and Maintenance) framework to guide a mixed-methods evaluation of the 3WP implementation in SNHs.

conclusionWe hypothesize that it will be feasible to adapt and implement the 3WP in SNHs. We will evaluate how the 3WP improves EOL care in this setting and provide valuable insight regarding the adaptations necessary to tailor palliative care interventions for SNH ICUs.

trial registrationClinicalTrials.gov NCT06277310.

Indexed as

Palliative CareSafety-net ProvidersTerminal CareHumansIntensive Care UnitsLos AngelesPragmatic Clinical Trials as Topic

Identifiers

PMID40315279
PMCPMC12047788

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.