ArticleInflammopharmacology2025
Ipomoea carnea Jacq. ameliorates formalin-induced paw inflammation in rats through modulation of oxidative and inflammatory pathways.
Article in Inflammopharmacology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Not yet cited in PubMed.
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Corrections and comments
- Erratum issued
Authors and funding
10 authors.
Funding
Abstract
Ipomoea carnea Jacq. (I. carnea) belongs to Convolvulaceae family, that is being for the management of pain and inflammation. Since long current research was conducted to study anti-inflammatory potential of aqueous methanolic extract of Ipomoea carnea (ICE). Preliminary proximate study and HPLC were carried out for the phytochemical characterization. The safety of ICE was ensured by acute oral toxicity study. In vitro anti-inflammatory potential of ICE was evaluated using BSA denaturation methods and egg albumin. In vivo inflamed paw rat model using formalin was done at doses of 150, 300, and 600 mg/kg. Diameter of the Paw, weight changes in the body, and biochemical and hematological markers were quantified. By means of ELISA IL-6, PGE-2, TNF-α, HSP-70, SOD, CAT, and MDA levels were measured. The mRNA expression of different inflammatory genes was evaluated by qRT-PCR. Effects of ICE were noted by histological and radiological findings. Phytochemistry of ICE identified the presence of different secondary metabolic constituents and HPLC identified the various phenolic compounds in the extract. Acute oral toxicity results showed that LD
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