Evidence map›Paper›PMID 40314905›Full record

ArticleAnnals of surgical oncology2025

The Ratio of the Preoperative Fecal Short-Chain Fatty Acid to Lactic Acid Concentrations as a Predictor of Postoperative Infectious Complications After Esophagectomy.

Takuya Nagao, Yukihiro Yokoyama, Tetsuya Abe, Kazushi Miyata, Shizuki Sugita, Atsushi Ogura, Yuki Murata, Eiji Higaki, Hironori Fujieda, Takashi Asahara and 2 more

Abstract read
PubMed Publisher
In one paragraph

Article in Annals of surgical oncology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Takuya NagaoDivision of Surgical Oncology, Department of Surgery, Nagoya University Graduate School of Medicine, Nagoya, Japan.
Yukihiro YokoyamaDivision of Surgical Oncology, Department of Surgery, Nagoya University Graduate School of Medicine, Nagoya, Japan. yokoyama.yukihiro.m9@f.mail.nagoya-u.ac.jp.ORCID http://orcid.org/0000-0003-2385-5610
Tetsuya AbeDepartment of Gastroenterological Surgery, Aichi Cancer Center Hospital, Nagoya, Japan.
Kazushi MiyataDivision of Surgical Oncology, Department of Surgery, Nagoya University Graduate School of Medicine, Nagoya, Japan.
Shizuki SugitaDivision of Surgical Oncology, Department of Surgery, Nagoya University Graduate School of Medicine, Nagoya, Japan.
Atsushi OguraDivision of Surgical Oncology, Department of Surgery, Nagoya University Graduate School of Medicine, Nagoya, Japan.
Yuki MurataDivision of Surgical Oncology, Department of Surgery, Nagoya University Graduate School of Medicine, Nagoya, Japan.
Eiji HigakiDepartment of Gastroenterological Surgery, Aichi Cancer Center Hospital, Nagoya, Japan.
Hironori FujiedaDepartment of Gastroenterological Surgery, Aichi Cancer Center Hospital, Nagoya, Japan.
Takashi AsaharaYakult Central Institute, Yakult Honsho Co., Ltd., Tokyo, Japan.
Yasuhiro ShimizuDepartment of Gastroenterological Surgery, Aichi Cancer Center Hospital, Nagoya, Japan.
Tomoki EbataDivision of Surgical Oncology, Department of Surgery, Nagoya University Graduate School of Medicine, Nagoya, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe ratio of the fecal short-chain fatty acid (SCFA) to lactic acid concentrations (APB-L ratio) is a useful indicator for the healthiness of the intestinal microenvironment. A recent study indicated that the low APB-L ratio can be a predictor of postoperative infectious complications (POICs) in patients undergoing pancreaticoduodenectomy. However, the predictive power of the APB-L ratio in other highly invasive surgeries, such as esophagectomy, is still unclear. This study investigated whether the APB-L ratio can be a sensitive predictor of POICs in patients undergoing esohpagectomy.

methodsA total of 129 patients undergoing esohpagectomy with gastric conduit reconstruction were included in this study. Preoperative fecal samples were analyzed for SCFA and lactic acid concentrations. The associations between clinical characteristics, POICs, and the APB-L ratio were analyzed. Preoperative and intraoperative risk factors for POICs were explored via multivariate logistic regression analysis.

resultsPostoperative infectious complications were observed in 34 patients (26%), including surgical site infections in 18 patients (14%). A low APB-L ratio was significantly associated with higher POICs and surgical site infections risk (both p < 0.05). A low APB-L ratio was identified as an independent risk factor for POICs, with an odds ratio of 3.62 (95% confidence interval, 1.44-9.10, p = 0.006).

conclusionsThe APB-L ratio measured with preoperative fecal organic acid concentrations is useful to assess the risk of POICs for esohpagectomy. The results also imply the importance of maintaining a healthy intestinal metabolism (thus high APB-L ratio) to reduce POICs before highly invasive surgery.

Indexed as

Esophageal NeoplasmsEsophagectomyFatty Acids, VolatileFecesLactic AcidPostoperative ComplicationsSurgical Wound InfectionAgedBiomarkersFemaleFollow-Up StudiesHumansMaleMiddle AgedPreoperative PeriodPrognosisBiomarkersFatty Acids, VolatileLactic AcidEsophagectomyFecal organic acidHighly invasive surgeryIntestinal microenvironmentLactic acid

Identifiers

PMID40314905

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.