Evidence map›Paper›PMID 40314897›Full record

ArticleAnnals of biomedical engineering2025

Relationship Between Rotational Device Kinematics and Head Kinematics in a Large Animal Model of Traumatic Brain Injury.

Declan A Patton, Ciara S Grunig, Jessica R McQuaid, Andrew B Dodd, Mandy K Pacheco, Josef M Ling, Tracey V Wick, Divyasree Sasi Kumar, Vadim Zotev, Rachel E Kinsler and 2 more

Abstract read
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In one paragraph

Article in Annals of biomedical engineering, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Declan A PattonCenter for Injury Research and Prevention, Children's Hospital of Philadelphia, Philadelphia, PA, USA. pattonda@chop.edu.ORCID http://orcid.org/0000-0003-1930-5421
Ciara S GrunigThe Mind Research Network/Lovelace Biomedical Research Institute, Pete & Nancy Domenici Hall, Albuquerque, NM, USA.
Jessica R McQuaidThe Mind Research Network/Lovelace Biomedical Research Institute, Pete & Nancy Domenici Hall, Albuquerque, NM, USA.
Andrew B DoddThe Mind Research Network/Lovelace Biomedical Research Institute, Pete & Nancy Domenici Hall, Albuquerque, NM, USA.
Mandy K PachecoThe Mind Research Network/Lovelace Biomedical Research Institute, Pete & Nancy Domenici Hall, Albuquerque, NM, USA.
Josef M LingThe Mind Research Network/Lovelace Biomedical Research Institute, Pete & Nancy Domenici Hall, Albuquerque, NM, USA.
Tracey V WickThe Mind Research Network/Lovelace Biomedical Research Institute, Pete & Nancy Domenici Hall, Albuquerque, NM, USA.
Divyasree Sasi KumarThe Mind Research Network/Lovelace Biomedical Research Institute, Pete & Nancy Domenici Hall, Albuquerque, NM, USA.
Vadim ZotevThe Mind Research Network/Lovelace Biomedical Research Institute, Pete & Nancy Domenici Hall, Albuquerque, NM, USA.
Rachel E KinslerEnroute Care Group, U.S. Army Aeromedical Research Laboratory, Fort Novosel, AL, USA.
Kristy B ArbogastCenter for Injury Research and Prevention, Children's Hospital of Philadelphia, Philadelphia, PA, USA.
Andrew R MayerThe Mind Research Network/Lovelace Biomedical Research Institute, Pete & Nancy Domenici Hall, Albuquerque, NM, USA.

Funding

U.S. Department of Defense W81XWH-16-DMRDP-CCCRP-PFCRAU.S. Department of Defense W81XWH2220067-TP210415
6 · The paper itself

Abstract

purposeLarge mammal head injury models allow the pathophysiological response associated with traumatic brain injury (TBI) to be studied in vivo with precise control of the physical parameters. However, only some studies have used skull-mounted sensors to measure the kinematics of the animal head rather than relying on measurements of the system delivering the impact. Therefore, the aim of the current study was to compare the kinematics between a rotational injury device (HYGE, Inc., Kittanning, PA) and the head in a swine model of TBI across a range of target peak angular velocities.

methodsSexually mature Yucatan swine were subjected to a rotational TBI via the HYGE device at one of three targeted peak angular velocities: 110 rad/s (n = 16), 145 rad/s (n = 12) or 170 rad/s (n = 11). Sensor packages were used to measure both the angular kinematics of the animal head and HYGE device swing arm.

resultsPeak angular velocity of the animal head was on average 18-33% lower compared to that of the HYGE device swing arm with greater relative differences for greater target peak angular velocities. Similarly, peak angular acceleration of the animal head was lower than that of the HYGE device sing arm by 11-34% on average with greater relative differences for greater target peak angular velocities.

conclusionsThis study highlights the importance of directly measuring the head kinematics of the animal in TBI models for the purpose of directional comparisons, finite element simulations, and/or scaling kinematics from human-to-animal to determine boundary conditions or animal-to-human to develop injury criteria.

Indexed as

Brain Injuries, TraumaticHeadAnimalsBiomechanical PhenomenaDisease Models, AnimalRotationSwineAnimal modelHead kinematicsTraumatic brain injury

Identifiers

PMID40314897

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.