Evidence map›Paper›PMID 40314863›Full record

ArticleBiologia futura2025

Effects of in vivo chlorobenzene exposure on bone tissue in a rat model.

Krisztián Sepp, Péter Hausinger, Béla Hegedűs, Péter Sándor Kiss, Edina Cseszkó, Miklós Mózes, Marianna Radács, Zsuzsanna Valkusz, Márta Gálfi, Zsolt Molnár

Abstract read
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In one paragraph

Article in Biologia futura, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Krisztián SeppDepartment of Internal Medicine, Albert Szent-Györgyi Medical School, University of Szeged, Szeged, Hungary.
Péter HausingerDepartment of Neurosurgery, Albert Szent-Györgyi Medical School, University of Szeged, Szeged, Hungary.
Béla HegedűsSS. Cosmas and Damian Rehabilitation Institute, Visegrád, Hungary.
Péter Sándor KissInstitute of Applied Health Sciences and Environmental Education, Department of Environmental Biology and Education, Juhász Gyula Faculty of Education, University of Szeged, 6. Boldogasszony Boulevard, 6725, Szeged, Hungary.
Edina CseszkóInstitute of Applied Health Sciences and Environmental Education, Department of Environmental Biology and Education, Juhász Gyula Faculty of Education, University of Szeged, 6. Boldogasszony Boulevard, 6725, Szeged, Hungary.
Miklós MózesInstitute of Applied Health Sciences and Environmental Education, Department of Environmental Biology and Education, Juhász Gyula Faculty of Education, University of Szeged, 6. Boldogasszony Boulevard, 6725, Szeged, Hungary.
Marianna RadácsInstitute of Applied Health Sciences and Environmental Education, Department of Environmental Biology and Education, Juhász Gyula Faculty of Education, University of Szeged, 6. Boldogasszony Boulevard, 6725, Szeged, Hungary.
Zsuzsanna ValkuszDepartment of Internal Medicine, Albert Szent-Györgyi Medical School, University of Szeged, Szeged, Hungary.
Márta GálfiInstitute of Applied Health Sciences and Environmental Education, Department of Environmental Biology and Education, Juhász Gyula Faculty of Education, University of Szeged, 6. Boldogasszony Boulevard, 6725, Szeged, Hungary.
Zsolt MolnárInstitute of Applied Health Sciences and Environmental Education, Department of Environmental Biology and Education, Juhász Gyula Faculty of Education, University of Szeged, 6. Boldogasszony Boulevard, 6725, Szeged, Hungary. molnar.zsolt.02@szte.hu.ORCID http://orcid.org/0000-0001-5176-149X

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Calcipaenic bone disorders (e.g., osteoporosis) are becoming an epidemic as a significant public health concern. The underlying genetic, epigenetic, and homeostatic factors and the determinants of bone tissue expression are triggered by environmental exposures. Endocrine disruptor compounds are important in the development of pathological bone alterations. The aim of this study is to design an in vivo subtoxic chlorobenzene exposure model that can be used to explore certain bone changes and their consequences. Male Wistar rats were treated via gastric tube with a 1:1 mixture of hexachlorobenzene + 1,2,4-trichlorobenzene at a dose of 1.0 μg/kg bw; in a final volume of 1 mL, for 30, 60 and 90 days. Blood serum and bone samples were obtained from the femur diaphysis. The results of the treatments (n = 10/group) were interpreted as related to the controls. Serum levels of γGT, SGOT, SGPT were determined, along with bone tissue morphology, as well as the total mineral content of the bone and the mobilizable anorganic content. ANOVA was used to analyze the measurement data. As a result of the treatment protocol, histological examinations of bone morphology showed osteoid degeneration, as well as an altered state of the bone matrix. These findings are supported by the DEXA images, which showed a time-dependent decrease in surface mineral content, in parallel, an increase in the mobilizable anorganic content of the bone was detected. These results suggest that chlorobenzene administered may be a causal factor and changes in bone tissue structure can be traced.

Indexed as

Bone and BonesChlorobenzenesAnimalsDisease Models, AnimalMaleRatsRats, WistarchlorobenzeneChlorobenzenesBoneChlorobenzenesEndocrine disruptor

Identifiers

PMID40314863

What OpenQuestion holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.