ArticleMaternal and child health journal2025
Association of Postpartum Cardiovascular Biomarkers with HIV Among Women with Recent Preeclampsia in Zambia.
Article in Maternal and child health journal, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
objectivesWomen recovering from preeclampsia with elevated vascular biomarkers have a higher risk of future cardiovascular diseases. We investigated whether HIV on treatment was associated with biomarkers of cardiovascular risk in the weeks following delivery.
methodsWe analyzed data from a six-month prospective cohort study conducted from January 2022 to June 2023. Following delivery and at six weeks postpartum, we measured cystatin C, high sensitivity C-reactive protein (hs-CRP), Interleukine-2 (IL-2), Interleukine-6 (IL-6) and Tumor necrosis factor-alpha (TNFa). A generalized linear regression model with Poisson distribution estimated the association between vascular biomarkers and HIV on treatment.
resultsThis study included 75 participants with a median age of 29 years (interquartile range [IQR] = 27-34 years), with 35 (46.7%) living with HIV on ART and 40 (53.3%) HIV-negative. Women living with HIV on ART had higher levels of hs-CRP than HIV-negative women (4.68 mg/l vs 3.60 mg/l, p = 0.025) at six weeks. On the other hand, women living with or without HIV on ART had similar levels of cystatin C (0.78 mg/l vs 0.81 mg/l, p = 0.303), IL-2 (0.64 pg/ml vs 0.67 pg/ml, p = 0.131), IL-6 (0.64 pg/ml vs 0.64 pg/ml, p = 0.422), and TNFa (24.2 pg/ml vs 24.1 pg/ml, p = 0.346). Living with HIV while on ART was associated with an increased risk of presenting as hypertensive with elevated hs-CRP (aRR = 2.88, 95% CI: 1.09-7.60).
conclusionsWomen living with HIV on ART had elevated hs-CRP but similar levels of other biomarkers after preeclampsia. Further studies are needed to explore the differential impact of HIV disease vs. antiretroviral treatment on inflammatory responses.
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