Evidence map›Paper›PMID 40314839›Full record

ArticleJournal of molecular neuroscience : MN2025

Oxidative Stress and Dynamic Thiol/Disulfide Homeostasis in Autism: A Focus on Early Childhood.

Halenur Teke, Senay Balci, Salim Neselioglu, Selçuk Teke, Ozcan Erel, Lulufer Tamer, Fevziye Toros

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of molecular neuroscience : MN, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Halenur TekeDepartment of Child and Adolescent Psychiatry, Medical Faculty, Mersin University, Ankara, Turkey. drhalenurteke@gmail.com.ORCID http://orcid.org/0009-0001-0143-3890
Senay BalciDepartment of Medical Biochemistry, Medical Faculty, Mersin University, Mersin, Turkey.ORCID http://orcid.org/0000-0002-7498-604X
Salim NeseliogluDepartment of Biochemistry, Ankara Bilkent City Hospital, Yıldırım Beyazit University, Ankara, Turkey.ORCID http://orcid.org/0000-0002-0974-5717
Selçuk TekeDepartment of Pediatrics, Medical Faculty, Mersin University, Ankara, Turkey.ORCID http://orcid.org/0000-0002-1885-6611
Ozcan ErelDepartment of Biochemistry, Ankara Bilkent City Hospital, Yıldırım Beyazit University, Ankara, Turkey.ORCID http://orcid.org/0000-0002-2996-3236
Lulufer TamerDepartment of Medical Biochemistry, Medical Faculty, Mersin University, Mersin, Turkey.ORCID http://orcid.org/0000-0002-0997-0260
Fevziye TorosDepartment of Child and Adolescent Psychiatry, Medical Faculty, Mersin University, Mersin, Turkey.ORCID http://orcid.org/0000-0001-5402-9157

Funding

Mersin University Scientific Research Coordination Office 2017-1 TP3-2198
6 · The paper itself

Abstract

Autism spectrum disorder (ASD) is a complex neurodevelopmental condition with multifactorial etiopathogenesis, where oxidative stress (OS) has been implicated as a key contributing factor. This study aimed to evaluate the plasma dynamic thiol/disulfide homeostasis (DTDH) parameters-a relatively novel OS biomarker-alongside classical OS biomarkers, including total oxidant status (TOS), total antioxidant status (TAS), oxidative stress index (OSI), glutathione, and glutathione peroxidase (GPx), in preschool children diagnosed with ASD. A total of 49 children with ASD and 31 age- and sex-matched typically developing children between the ages of 2 and 6 years were included. In addition to sociodemographic data collection, the Childhood Autism Rating Scale (CARS) and Clinical Global Impression-Severity Scale (CGI-S) were administered to assess autism severity. Blood samples were analyzed using automated spectrophotometric techniques to determine OS biomarkers. The results demonstrated that DTDH parameters and classical OS markers exhibited parallel changes; however, no statistically significant differences were detected between the ASD and control groups across all OS markers. Furthermore, no significant association was found between OS biomarkers and autism severity. Moreover, we intentionally restricted our sample to a younger age group to enable a focused examination of OS dynamics during early developmental stages. This study underscores the potential impact of age as a critical determinant in OS-related alterations in autism and highlights the need for further age-stratified investigations to elucidate the role of OS in ASD pathophysiology and its potential diagnostic relevance.

Indexed as

Autism Spectrum DisorderDisulfidesOxidative StressSulfhydryl CompoundsAutistic DisorderBiomarkersChildChild, PreschoolFemaleGlutathioneGlutathione PeroxidaseHomeostasisHumansMaleBiomarkersDisulfidesGlutathioneGlutathione PeroxidaseSulfhydryl CompoundsAutism spectrum disorderBiomarkersDynamic thiol/disulfide homeostasisEarly childhoodOxidative stress

Identifiers

PMID40314839
PMCPMC12048410

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.