Evidence map›Paper›PMID 40314697›Full record

ArticleEnvironmental health perspectives2025

Long-Term Exposure to Air Pollution and Incidence of Type 2 Diabetes in the Nurses' Health Study and Nurses' Health Study II.

Melissa R Fiffer, Jie Chen, Emily L Silva, Rachel C Nethery, Qi Sun, Peter James, Stephanie T Grady, Jeff D Yanosky, Joel D Kaufman, Francine Laden and 1 more

Abstract read
In one paragraph

Article in Environmental health perspectives, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Melissa R FifferChildren's Environmental Health Initiative, University of Illinois Chicago, Chicago, Illinois, USA.ORCID 0000-0003-0188-5229
Jie ChenDepartment of Environmental Health, Harvard T.H. Chan School of Public Health, Boston, Massachusetts, USA.
Emily L SilvaDepartment of Environmental Health, Harvard T.H. Chan School of Public Health, Boston, Massachusetts, USA.
Rachel C NetheryDepartment of Biostatistics, Harvard T.H. Chan School of Public Health, Boston, Massachusetts, USA.
Qi SunDepartment of Nutrition, Harvard T.H. Chan School of Public Health, Boston, Massachusetts, USA.
Peter JamesDepartment of Environmental Health, Harvard T.H. Chan School of Public Health, Boston, Massachusetts, USA.
Stephanie T GradyDepartment of Environmental Health, Boston University School of Public Health, Boston, Massachusetts, USA.
Jeff D YanoskyDepartment of Public Health Sciences, The Pennsylvania State University College of Medicine, Hershey, Pennsylvania, USA.
Joel D KaufmanDepartment of Environmental & Occupational Health Sciences, University of Washington, Seattle, Washington, USA.
Francine LadenDepartment of Environmental Health, Harvard T.H. Chan School of Public Health, Boston, Massachusetts, USA.
Jaime E HartDepartment of Environmental Health, Harvard T.H. Chan School of Public Health, Boston, Massachusetts, USA.

Funding

Translational Research Support CoreP30ES000002 · NIEHS · HARVARD UNIVERSITY (SCH OF PUBLIC HLTH) · PI JAIME ELIZABETH HART · 1985 to 2026
$44.6M
XENOBIOTIC BIOTRANSFORMATION AND DISPOSITIONP30ES007033 · NIEHS · UNIVERSITY OF WASHINGTON · PI Nicole Ann Errett · 1995 to 2026
$42.5M
Long Term Multidisciplinary Study of Cancer in Women: The Nurses Health StudyUM1CA186107 · NCI · BRIGHAM AND WOMEN'S HOSPITAL · PI ELIASSEN, A. HEATHER, STAMPFER, MEIR · 2014 to 2023
$22.3M
Integrating lifecourse approaches, biologic and digital phenotypes in support of heart and lung disease epidemiologic researchU01HL145386 · NHLBI · HARVARD UNIVERSITY D/B/A HARVARD SCHOOL OF PUBLIC HEALTH · PI CHAVARRO, JORGE EDUARDO, MANSON, JOANN ELISABETH · 2019 to 2025
$17.8M
Training Program in Environmental EpidemiologyT32ES007069 · NIEHS · HARVARD UNIVERSITY (SCH OF PUBLIC HLTH) · PI LADEN, FRANCINE · 1985 to 2024
$13.9M
Built Environment Assessment through Computer visiON (BEACON): Applying Deep Learning to Street-Level and Satellite Images to Estimate Built Environment Effects on Cardiovascular HealthR01HL150119 · NHLBI · UNIVERSITY OF CALIFORNIA AT DAVIS · PI JAMES, PETER · 2020 to 2024
$3.9M
Relationship Between Multiple Environmental Exposures and CVD Incidence and Survival: Vulnerability and SusceptibilityR01ES028033 · NIEHS · HARVARD SCHOOL OF PUBLIC HEALTH · PI DOMINICI, FRANCESCA, LADEN, FRANCINE · 2018 to 2022
$3.5M
Air Pollutants and Cardiovascular Risk: Investigating Thresholds with Pooled Cohorts and Electronic Health RecordsR01ES027696 · NIEHS · UNIVERSITY OF WASHINGTON · PI KAUFMAN, JOEL DANIEL, VAN DEN EEDEN, STEPHEN K. · 2017 to 2020
$2.5M
Causal machine learning methods for studying the effects of environmental exposures on childhood cancer using natural experimentsK01ES032458 · NIEHS · HARVARD SCHOOL OF PUBLIC HEALTH · PI NETHERY, RACHEL C · 2021 to 2023
$417k
NCI NIH HHS UM1 CA186107NHLBI NIH HHS R01 HL150119NHLBI NIH HHS U01 HL145386NIEHS NIH HHS K01 ES032458NIEHS NIH HHS P30 ES000002NIEHS NIH HHS P30 ES007033NIEHS NIH HHS R01 ES027696NIEHS NIH HHS R01 ES028033NIEHS NIH HHS T32 ES007069
6 · The paper itself

Abstract

backgroundResearch has detected associations between air pollution exposure and type 2 diabetes (T2DM), but findings from large cohort studies are needed to ascertain the most influential pollutants, susceptible subpopulations, and low-level exposure associations. Our aim was to prospectively evaluate the association between long-term exposure to fine particulate matter

methodsMonthly

resultsOver follow-up, there were 19,083 incident T2DM cases among the 208,733 women in NHS and NHSII. In fully adjusted single-pollutant models, the hazard ratio (HR) for an interquartile range (IQR) (

conclusionsOur results showed a positive association between T2DM and long-term exposure to

Indexed as

Air PollutantsAir PollutionDiabetes Mellitus, Type 2Environmental ExposureAdultFemaleHumansIncidenceMiddle AgedNitrogen DioxideNursesParticulate MatterProspective StudiesUnited StatesAir PollutantsNitrogen DioxideParticulate Matter

Identifiers

PMID40314697
PMCPMC12161454

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.