ArticleJournal of the American Heart Association2025
Total and Structural Carotid Artery Stiffness Are Associated With Cognitive Decline and Structural Brain Abnormalities Related to Alzheimer Disease and Alzheimer Disease-Related Dementias Pathology: The Multi-Ethnic Study of Atherosclerosis.
Article in Journal of the American Heart Association, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed.
- Changes in arterial stiffness under blood pressure control are independently associated with cognitive impairment: The Systolic Blood Pressure Intervention Trial (SPRINT).Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Trial
- Exploring the link between body physiology and cognition: the role of the brain and aging.npj aging · 2026Article
- Article
- Associations of urinary isoprostanes with structural and load-dependent arterial stiffness: the Multi-Ethnic Study of Atherosclerosis.American journal of physiology. Heart and circulatory physiology · 2026Article
- Evaluation of an in vivo biomarker of arteriolosclerosis (ARTS) and its associations with cognition and multimodal ATN(V) biomarkers in a cardiometabolic-risk enriched community cohort.medRxiv : the preprint server for health sciences · 2025Article
- Carotid and regional arterial stiffness and dementia-related imaging biomarkers in the Multi-Ethnic Study of Atherosclerosis (MESA).Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025Article
- Arterial stiffness and risk of dementia in late life: The ARIC neurocognitive study.Alzheimer's & dementia (Amsterdam, Netherlands)Article
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Authors and funding
15 authors.
Funding
Abstract
backgroundArterial stiffness is associated with pathological changes underlying Alzheimer disease and related dementias. Total pulse wave velocity can be subdivided into 2 main mechanisms: structural arterial stiffness (S-PWV) due to intrinsic remodeling of the artery wall and load-dependent arterial stiffness due to increased blood pressure. METHODS AND
resultsIn this prospective cohort study, MESA (Multi-Ethnic Study of Atherosclerosis) participants completed B-mode carotid ultrasounds from which carotid total pulse wave velocity was calculated. S-PWV was calculated by adjusting pulse wave velocity to 120/80 mmHg using a nonlinear pressure-diameter relationship, and load-dependent arterial stiffness was derived by subtracting S-PWV from total pulse wave velocity. Participants had repeated cognitive assessments with the Cognitive Abilities Screening Instrument, Digit Symbol Coding, and Digit Span combined into a global cognitive composite (N=2489). Brain magnetic resonance imaging was used to generate total gray matter volume (N=906), white matter hyperintensity volume (N=896), and total white matter fractional anisotropy (N=810). Multivariable linear fixed and mixed effects regression models related standardized pulse wave velocity components to neuroimaging and cognitive decline parameters, respectively. Greater S-PWV was associated with greater longitudinal cognitive decline in global cognitive composite score (β=-0.05,
conclusionsHigher structural stiffness of the carotid artery is associated with cognitive decline, whereas both structural and load-dependent stiffness are associated with brain structural abnormalities common in Alzheimer disease-related dementias.
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