ArticleJournal of the American Heart Association2025
Atrial Fibrillation, Venous Thromboembolism, and Risk of Pulmonary Hypertension: A Swedish Nationwide Register Study.
Article in Journal of the American Heart Association, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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Who cites it
3 citing papers in PubMed.
- Efficacy of Catheter Ablation in Atrial Fibrillation Patients With Pulmonary Hypertension.Pacing and clinical electrophysiology : PACE · 2026Article
- Visceral Embolic Events in Atrial Fibrillation: A Systematic Review and Meta-Analysis of Incidence, Mortality, and Risk Prediction.Journal of clinical medicine · 2025Review
- Arrhythmias across the tree of life: comparative insights for human electrophysiology.Frontiers in cardiovascular medicine · 2025Review
Corrections and comments
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundAtrial fibrillation (AF) is suggested to be associated with venous thromboembolism (VTE) and might thereby play a role in the development of chronic thromboembolic pulmonary hypertension (PH). By elevating left-sided filling pressure and promoting atrial myopathy, AF may also play a role in the development of postcapillary PH. We aimed to investigate the association between AF, with or without incident VTE, and the occurrence of PH.
methodsA total of 521 988 patients diagnosed with AF between 1987 and 2013, without a previous diagnosis of VTE or PH, were identified from the Swedish National Patient Register and matched for age, sex, and county with 1 017 277 population controls without AF, VTE, or PH.
resultsThe mean age of the patients with AF was 71.1 (SD ±10.1) years and 42.8% were women. During a median follow-up period of 11 (interquartile range 5.1-17) years, 4454 (0.9%) patients with AF, and 1855 (0.2%) controls were diagnosed with PH, hazard ratio 4.7 (4.4-5.0). The AF group had a significantly higher comorbidity burden at baseline, with a mean CHA
conclusionsAF was associated with a markedly increased risk of developing incident PH, and this risk was further increased by incident VTE.
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