Evidence map›Paper›PMID 40314356›Full record

ArticleJournal of the American Heart Association2025

Association of a Comprehensive ST-Segment-Elevation Myocardial Infarction Protocol With Key Process Metrics Among Patients Transferred for Primary Percutaneous Coronary Intervention.

Radoslav Zinoviev, Anirudh Kumar, Chetan P Huded, Michael Johnson, Kathleen Kravitz, Grant W Reed, Amar Krishnaswamy, Damon Michael Kralovic, Fredric M Hustey, Abigail S Brown and 2 more

Abstract read
In one paragraph

Article in Journal of the American Heart Association, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Radoslav ZinovievDivision of Cardiology University of California Los Angeles Los Angeles CA USA.ORCID 0000-0002-0619-426X
Anirudh KumarNorthwestern Central DuPage Hospital Winfield IL USA.ORCID 0000-0002-4413-5439
Chetan P HudedSaint Luke's Mid America Heart Institute Kansas City MO USA.ORCID 0000-0003-0151-5471
Michael JohnsonPiedmont Augusta Hospital Augusta GA USA.ORCID 0000-0002-4096-7916
Kathleen KravitzCleveland Clinic Heart Vascular and Thoracic Institute Cleveland OH USA.
Grant W ReedCleveland Clinic Heart Vascular and Thoracic Institute Cleveland OH USA.ORCID 0000-0001-8234-3135
Amar KrishnaswamyCleveland Clinic Heart Vascular and Thoracic Institute Cleveland OH USA.ORCID 0000-0001-6048-7955
Damon Michael KralovicCleveland Clinic Heart Vascular and Thoracic Institute Center for Healthcare Delivery Innovation Cleveland OH USA.
Fredric M HusteyCleveland Clinic Heart Vascular and Thoracic Institute Center for Healthcare Delivery Innovation Cleveland OH USA.
Abigail S BrownCleveland Clinic Heart Vascular and Thoracic Institute Center for Healthcare Delivery Innovation Cleveland OH USA.
Samir R KapadiaCleveland Clinic Heart Vascular and Thoracic Institute Cleveland OH USA.ORCID 0000-0002-0026-3391
Umesh N KhotCleveland Clinic Heart Vascular and Thoracic Institute Cleveland OH USA.ORCID 0000-0001-6121-1280

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundMost US patients with ST-segment-elevation myocardial infarction (STEMI) transferred for percutaneous coronary intervention (PCI) do not achieve the goal door-to-balloon time (D2BT) of ≤120 minutes. We evaluated the impact of a comprehensive STEMI protocol (CSP) implemented in our health care system on STEMI process metrics in patients transferred for PCI. METHODS AND

resultsThe CSP is a 4-step protocol including (1) emergency department (ED) cardiac catheterization laboratory activation; (2) a STEMI Safe Handoff Checklist; (3) immediate transfer to an available cardiac catheterization laboratory; and (4) radial-first approach to PCI. We compared the use of guideline-directed medical therapy before angiography, radial-first access, and D2BT in 1274 consecutive patients with STEMI transferred to our hospital for PCI before (pre-CSP group; January 1, 2011, to July 14, 2014) and after (CSP group; July 15, 2014, to July 15, 2019) CSP implementation. The study population included 499 patients in the pre-CSP group and 775 patients in the CSP group. After CSP implementation, guideline-directed medical therapy before angiography (84.6% versus 93.9%,

conclusionsIn patients with STEMI transferred for PCI, a standardized protocol for STEMI care was associated in improvements in key process metrics (guideline-directed medical therapy, radial access, and D2BT) with associated reduction in the 30-day mortality rate.

Indexed as

Clinical ProtocolsPatient TransferPercutaneous Coronary InterventionST Elevation Myocardial InfarctionTime-to-TreatmentAgedCardiac CatheterizationCoronary AngiographyEmergency Service, HospitalFemaleHumansMaleMiddle AgedRetrospective StudiesTime FactorsTreatment Outcomecare protocolshospital transferST‐segment–elevation myocardial infarction (STEMI)

Identifiers

PMID40314356
PMCPMC12184277

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.