Observational studyJournal of the American Heart Association2025
Right Ventricular-Pulmonary Artery Uncoupling and Strain in Acute Heart Failure.
Observational study in Journal of the American Heart Association, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02638142 (Continuous Versus Bolus Intermittent Loop Diuretic Infusion in Acutely Decompensated Heart Failure), which is not on this map. Cited by 6 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Continuous Versus Bolus Intermittent Loop Diuretic Infusion in Acutely Decompensated Heart Failure: Evaluation of Renal Function, Congestion Signs, BNP and Outcome
Who cites it
6 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Ventriculo-arterial coupling in acute heart failure: prognostic and therapeutic insights - a systematic review and meta-analysis of multivariable-adjusted data.Heart failure reviews · 2026Pooled it
- The predictive value of the TAPSE/PASP ratio for major adverse cardiovascular events in patients with chronic heart failure: evidence from a prolonged follow-up cohort.Annals of medicine · 2026Article
- Article
- TAPSE/PASP ratio as a prognostic marker in HFmrEF: a missed opportunity?Heart and vessels · 2026Article
- Reply to "TAPSE/PASP Ratio as a Prognostic Marker in HFmrEF: A Missed Opportunity?"Heart and vessels · 2026Article
- Chronic Right Heart Failure: Pathogenesis, Haemodynamic Foundations, and a Pragmatic Diagnostic Algorithm.Journal of cardiovascular development and disease · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundAssessment of right ventricular-pulmonary artery coupling plays a crucial role in risk stratification, monitoring efficacy, and predicting outcomes in chronic heart failure patients. However, data in acute heart failure (AHF) are still lacking. METHODS AND
resultsThis multicenter observational study includes 425 patients with AHF: 248 with reduced left ventricular ejection fraction (<50%) and 177 with preserved left ventricular ejection fraction (≥50%). Pulmonary artery systolic pressure (PASP), tricuspid annular plane systolic excursion (TAPSE), longitudinal 2-dimensional strain of right ventricular (RV) free wall, and the RV end-diastolic diameter were measured by echocardiography. TAPSE/PASP and longitudinal 2-dimensional strain of RV free wall/PASP ratios were calculated as noninvasive surrogates of right ventricular-pulmonary artery coupling. The end point was a composite of all-cause death/HF-related hospitalizations assessed at 180 days. At 180 days, 197 patients (46.4%) reached the end point. After multivariable adjustment for RV end-diastolic diameter, E/e' ratio, left ventricular ejection fraction, and natriuretic peptides, although both TAPSE/PASP (hazard ratio [HR], 0.49 [95% CI, 0.25-0.27];
conclusionsIn patients with AHF, both TAPSE/PASP and longitudinal 2-dimensional strain of RV free wall/PASP are independent predictor of prognosis. However, longitudinal 2-dimensional strain of RV free wall/PASP showed a superior discriminator capability in identifying patients with events, mainly in the AHF with preserved ejection fraction subgroup. REGISTRATION: URL: https://www.clinicaltrials.gov; Unique Identifier: NCT02638142.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.