Evidence map›Paper›PMID 40314170›Full record

ArticlePsychological medicine2025

Cognitive and neural abnormalities: working memory deficits in bipolar disorder offspring.

Ye Xie, Wenjin Zou, Yuanqi Shang, Weicong Lu, Xiaoyue Li, Qi Chen, Robin Shao, Yixuan Ku, Kangguang Lin

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Psychological medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Ye XieSchool of Psychology, Shenzhen University, Shenzhen, P.R. China.
Wenjin ZouDepartment of Affective Disorder, The Affiliated Brain Hospital, Guangzhou Medical University, Guangzhou, P.R. China.
Yuanqi ShangGuangdong Provincial Key Laboratory of Brain Function and Disease, Center for Brain and Mental Wellbeing, Department of Psychology, Sun Yat-sen University, Guangzhou, P.R. China.
Weicong LuDepartment of Affective Disorder, The Affiliated Brain Hospital, Guangzhou Medical University, Guangzhou, P.R. China.
Xiaoyue LiDepartment of Affective Disorder, The Affiliated Brain Hospital, Guangzhou Medical University, Guangzhou, P.R. China.
Qi ChenSchool of Psychology, Shenzhen University, Shenzhen, P.R. China.
Robin ShaoState Key Laboratory of Brain and Cognitive Sciences, Department of Psychology, University of Hong Kong, Hong Kong, P.R. China.
Yixuan KuGuangdong Provincial Key Laboratory of Brain Function and Disease, Center for Brain and Mental Wellbeing, Department of Psychology, Sun Yat-sen University, Guangzhou, P.R. China.
Kangguang LinDepartment of Affective Disorder, The Affiliated Brain Hospital, Guangzhou Medical University, Guangzhou, P.R. China.ORCID 0000-0003-4027-5554

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundOffspring of parents with bipolar disorder (BD offspring) face elevated risks for emotional dysregulation and cognitive deficits, particularly in working memory. This study investigates working memory deficits and their neural correlates in BD offspring.

methodsWe assessed 41 BD offspring and 25 age-matched healthy controls (HCs) using a spatial N-back task and task-related functional magnetic resonance imaging (fMRI).

resultsCompared to HCs, BD offspring exhibit reduced accuracy and lower signal-detection sensitivity (

conclusionsThese findings suggest that BD offspring exhibit working memory deficits and impaired neural connectivity involving both sensory processing and higher-order cognitive systems. Such deficits may emerge at a genetically predisposed stage of bipolar disorder, underscoring the significance of early identification and intervention strategies.

Indexed as

Bipolar DisorderChild of Impaired ParentsCognitive DysfunctionMemory, Short-TermAdolescentAdultCase-Control StudiesFemaleHumansMagnetic Resonance ImagingMaleYoung AdultBD offspringbipolar disorderfunctional magnetic resonance imagingprefrontal cortexworking memory

Identifiers

PMID40314170
PMCPMC12094646

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.