ArticlePsychological medicine2025
A longitudinal analysis of the relationship between emotional symptoms and cognitive function in patients with major depressive disorder.
Article in Psychological medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed.
- Predictors of Improvement in Subjective Executive Functioning Following an Internet-Delivered Cognitive Enhancement Intervention for Adults in Remission From Depression.Acta psychiatrica Scandinavica · 2026Trial
- Suicidal ideation and cognitive function: a comparative study in adolescents with unipolar versus bipolar depression.European archives of psychiatry and clinical neuroscience · 2026Article
- Cognitive Symptoms and Overall Functioning During Major Depressive Episodes: Correlation Analysis of Patients With Unipolar and Bipolar Disorders.Depression and anxiety · 2026Observational
- Layered vulnerabilities in young adults with major depressive disorder: personality, coping, and cognition.Frontiers in psychiatry · 2026Article
- Exploring the neural mechanisms of electroacupuncture for cognitive impairment in depression using functional near-infrared spectroscopy: a randomized controlled trial.Frontiers in psychiatry · 2025Article
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Authors and funding
12 authors.
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Abstract
backgroundThe relationship between emotional symptoms and cognitive impairments in major depressive disorder (MDD) is key to understanding cognitive dysfunction and optimizing recovery strategies. This study investigates the relationship between subjective and objective cognitive functions and emotional symptoms in MDD and evaluates their contributions to social functioning recovery.
methodsThe Prospective Cohort Study of Depression in China (PROUD) involved 1,376 MDD patients, who underwent 8 weeks of antidepressant monotherapy with assessments at baseline, week 8, and week 52. Measures included the Hamilton Depression Rating Scale (HAMD-17), Quick Inventory of Depressive Symptomatology-Self Report (QIDS-SR16), Chinese Brief Cognitive Test (C-BCT), Perceived Deficits Questionnaire for Depression-5 (PDQ-D5), and Sheehan Disability Scale (SDS). Cross-lagged panel modeling (CLPM) was used to analyze temporal relationships.
resultsDepressive symptoms and cognitive measures demonstrated significant improvement over 8 weeks (
conclusionsSubjective cognitive dysfunction is more strongly associated with depressive symptoms and plays a significant role in social functioning recovery, highlighting the need for targeted interventions addressing subjective cognitive deficits in MDD.
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