Evidence map›Paper›PMID 40313982›Full record

ArticlemLife2025

Engineering archaeal membrane-spanning lipid GDGT biosynthesis in bacteria: Implications for early life membrane transformations.

Huahui Chen, Fengfeng Zheng, Xi Feng, Zijing Huang, Wei Yang, Chuanlun Zhang, Wenbin Du, Kira S Makarova, Eugene V Koonin, Zhirui Zeng

Abstract read
In one paragraph

Article in mLife, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Huahui ChenDepartment of Ocean Science and Engineering Southern University of Science and Technology Shenzhen China.ORCID 0000-0001-7423-131X
Fengfeng ZhengDepartment of Ocean Science and Engineering Southern University of Science and Technology Shenzhen China.
Xi FengDepartment of Ocean Science and Engineering Southern University of Science and Technology Shenzhen China.
Zijing HuangDepartment of Ocean Science and Engineering Southern University of Science and Technology Shenzhen China.
Wei YangDepartment of Ocean Science and Engineering Southern University of Science and Technology Shenzhen China.
Chuanlun ZhangDepartment of Ocean Science and Engineering Southern University of Science and Technology Shenzhen China.
Wenbin DuState Key Laboratory of Microbial Resources, Institute of Microbiology Chinese Academy of Sciences Beijing China.ORCID 0000-0002-7401-1410
Kira S MakarovaNational Center for Biotechnology Information, National Library of Medicine Bethesda Maryland USA.
Eugene V KooninNational Center for Biotechnology Information, National Library of Medicine Bethesda Maryland USA.
Zhirui ZengDepartment of Ocean Science and Engineering Southern University of Science and Technology Shenzhen China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Eukaryotes are hypothesized to be archaeal-bacterial chimeras. Given the different chemical structures of membrane phospholipids in archaea and bacteria, transformations of membranes during eukaryogenesis that led to the bacterial-type membranes of eukaryotic cells remain a major conundrum. One of the possible intermediates of eukaryogenesis could involve an archaeal-bacterial hybrid membrane. So far, organisms with hybrid membranes have not been discovered, and experimentation on such membranes has been limited. To generate mixed membranes, we reconstructed the archaeal membrane lipid biosynthesis pathway in

Indexed as

archaeal lipid GDGTcellular filamentationeukaryogenesishybrid membraneSOS response

Identifiers

PMID40313982
PMCPMC12042123

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.