Evidence map›Paper›PMID 40313956›Full record

ArticleFrontiers in immunology2025

Merocytophagy is an integrin-stabilized macrophage response to microbes reliant on Syk signaling.

Kelly N Deobald, Shaun P Steele, Sedelia R Dominguez, Shannon Whiles, Thomas Kawula

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in immunology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Kelly N DeobaldAllen School for Global Health, Washington State University, Pullman, WA, United States.
Shaun P SteeleAllen School for Global Health, Washington State University, Pullman, WA, United States.
Sedelia R DominguezAllen School for Global Health, Washington State University, Pullman, WA, United States.
Shannon WhilesAllen School for Global Health, Washington State University, Pullman, WA, United States.
Thomas KawulaAllen School for Global Health, Washington State University, Pullman, WA, United States.

Funding

TRAINING IN BIOTECHNOLOGY: EMPHASIS ON PROTEIN CHEMISTRYT32GM008336 · NIGMS · WASHINGTON STATE UNIVERSITY · PI CALL, DOUGLAS R. · 1989 to 2023
$8.9M
Impact of cytosolic material acquisition by macrophages and dendritic cells on the immune response to intracellular pathogensR56AI139476 · NIAID · WASHINGTON STATE UNIVERSITY · PI KAWULA, THOMAS H · 2019 to 2019
$261k
NIAID NIH HHS R56 AI139476NIGMS NIH HHS T32 GM008336
6 · The paper itself

Abstract

Macrophages and dendritic cells acquire bacteria and cytosolic content from other cells without killing the donor cell through a trogocytosis-associated process termed merocytophagy. While characteristics of this behavior have been partially identified, the mechanism and potential contribution to the response to infection are unclear. Here, we reveal that a wide range of distinct species of bacteria stimulate enhanced merocytophagy in macrophages through pattern recognition receptor (PRR). Further, we found that cell-to-cell transfer in response to

Indexed as

Francisella tularensisIntegrinsMacrophagesSignal TransductionSyk KinaseAnimalsMiceMice, Inbred C57BLMice, KnockoutPhagocytosisReceptors, Pattern RecognitionIntegrinsReceptors, Pattern RecognitionSyk KinaseSyk protein, mousebacterial pathogensICAM-1innate immunityintegrin alpha 4integrin beta 2macrophageSyktrogocytosis

Identifiers

PMID40313956
PMCPMC12043706

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.