Evidence map›Paper›PMID 40313926›Full record

ArticlebioRxiv : the preprint server for biology2025

Apparent cooperativity between human CMV virions introduces errors in conventional methods of calculating multiplicity of infection.

Christopher Peterson, Joshua Miller, Brent J Ryckman, Vitaly V Ganusov

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

4 authors.

Christopher PetersonDepartment of Biological Studies, College of Humanities and Sciences, University of Montana, MT, USA.
Joshua MillerDepartment of Geographical Sciences, University of Bristol, Bristol, UK.
Brent J RyckmanDepartment of Biological Studies, College of Humanities and Sciences, University of Montana, MT, USA.
Vitaly V GanusovHost-Pathogen Interactions program, Texas Biomedical Research Institute, San Antonio, TX 78227, USA.ORCID 0000-0001-6572-1691

Funding

HCMV gH/gL complexes: Distinct roles for epithelial cell tropism, and implications for antibody neutralization.R01AI097274 · NIAID · UNIVERSITY OF MONTANA · PI RYCKMAN, BRENT J. · 2012 to 2020
$3.4M
Mathematical modeling of Mycobacterium tuberculosis disseminationR01AI158963 · NIAID · UNIVERSITY OF TENNESSEE KNOXVILLE · PI Vitaly V. Ganusov · 2022 to 2026
$3.2M
NIAID NIH HHS R01 AI097274NIAID NIH HHS R01 AI158963
6 · The paper itself

Abstract

Whether infection of cells by individual virions occurs randomly or if there is some form(s) of competition or cooperativity between individual virions remains largely unknown for most virus-cell associations. Here we studied cooperativity/competition for three different strains of human cytomegalovirus (

Indexed as

flow cytometryhuman cytomegalovirusinfectivitymathematical modelmultiplicity of infectionvirus cooperativity

Identifiers

PMID40313926
PMCPMC12045349

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.