Evidence map›Paper›PMID 40313924›Full record

ArticlebioRxiv : the preprint server for biology2025

Xian Wang, Ling Ding, Shenyu Sun, Suet Kee Loo, Luping Chen, Tingting Li, Man-Tzu Wang, Arjun Pennathur, Yufei Huang, Shou-Jiang Gao

Abstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Xian WangCancer Virology Program, UPMC Hillman Cancer Center, Pittsburgh, PA 15213, USA.
Ling DingCancer Virology Program, UPMC Hillman Cancer Center, Pittsburgh, PA 15213, USA.
Shenyu SunCancer Virology Program, UPMC Hillman Cancer Center, Pittsburgh, PA 15213, USA.
Suet Kee LooCancer Virology Program, UPMC Hillman Cancer Center, Pittsburgh, PA 15213, USA.
Luping ChenCancer Virology Program, UPMC Hillman Cancer Center, Pittsburgh, PA 15213, USA.
Tingting LiCancer Virology Program, UPMC Hillman Cancer Center, Pittsburgh, PA 15213, USA.
Man-Tzu WangCancer Biology Program, UPMC Hillman Cancer Center, Pittsburgh, PA 15213, USA.
Arjun PennathurDepartment of Cardiothoracic Surgery, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA.
Yufei HuangCancer Virology Program, UPMC Hillman Cancer Center, Pittsburgh, PA 15213, USA.
Shou-Jiang GaoCancer Virology Program, UPMC Hillman Cancer Center, Pittsburgh, PA 15213, USA.

Funding

VECTOR CORE FACILITYP30CA047904 · NCI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI CHRISTOPHER J. BAKKENIST · 1988 to 2026
$158.0M
Cell Model for KSHV Infection and Genetic ManipulationR01CA096512 · NCI · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI Shou-Jiang Gao · 2003 to 2026
$7.4M
Regulation of KSHV replication by N6-methyladenosine (m6A) - Diversity SupplementR01CA124332 · NCI · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI GAO, SHOU-JIANG · 2007 to 2025
$5.0M
Impact of microbiota on AIDS-Kaposi’s sarcoma development and therapyR01CA284554 · NCI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI Shou-Jiang Gao · 2023 to 2026
$3.1M
Citrulline-urea cycle in KSHV cellular transformationR01CA278812 · NCI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI Shou-Jiang Gao · 2023 to 2026
$2.1M
METTL16 and S-adenosylmethionine cycle in KSHV infectionR01CA291244 · NCI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI Shou-Jiang Gao · 2025 to 2026
$1.3M
NCI NIH HHS P30 CA047904NCI NIH HHS R01 CA096512NCI NIH HHS R01 CA124332NCI NIH HHS R01 CA278812NCI NIH HHS R01 CA284554NCI NIH HHS R01 CA291244
6 · The paper itself

Abstract

Cytosolic arginine sensor for mTORC1 Subunit 1 (CASTOR1) functions as a key regulator of mechanistic target of rapamycin complex 1 (mTORC1) signaling. Despite its frequent dysregulation in cancers via mechanisms such as KSHV microRNA-mediated inhibition or AKT-driven phosphorylation and degradation, the impact of

Indexed as

CASTOR1combination therapyERKgenomic instabilityKRAS-driven NSCLCKRAS inhibitor resistancemTORC1tumor suppressor

Identifiers

PMID40313924
PMCPMC12045348

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.