ArticleACS sustainable chemistry & engineering2025
Carboxylic Acid Concentration in Downstream Bioprocessing Using High-Pressure Reverse Osmosis.
Article in ACS sustainable chemistry & engineering, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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Who cites it
2 citing papers in PubMed.
- Performance comparison of downstream unit operations and process chains for the purification of amino acids for food, feed and pharma applications.Biotechnology reports (Amsterdam, Netherlands) · 2026Review
- One-pot bioprocessing: dynamics and opportunities for integrated multiproduct recovery-a review.Bioprocess and biosystems engineering · 2026Review
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Authors and funding
9 authors.
Funding
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Abstract
During the production of many bio-based chemicals from fermentation and enzymatic processes, product separations frequently represent the most expensive and energy-intensive unit operations in an integrated process, often due to the low concentrations of target bioproducts. In this study, we integrated high-pressure reverse osmosis (HPRO) to concentrate an exemplary fermentation product, butyric acid, prior to downstream extraction. Through both modeling and experimental measurements, we identified the major factors limiting the maximum achievable concentration factor (CF) of 4.0 for butyric acid concentration with an HPRO membrane compared to the 2.6-3.2 range for conventional reverse osmosis (RO) membranes. The resulting concentrated aqueous stream underwent liquid-liquid extraction with an organic solvent and distillation for butyric acid purification and solvent recycling. The integration of HPRO product concentration into an
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Registered trials
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