Evidence map›Paper›PMID 40313767›Full record

ArticleResearch square2025

Tafazzin-Deficient Zebrafish Display Mitochondrial Dysfunction, Neutropenia, and Metabolic Defects Without Myopathy.

Usua Oyarbide, Rebecca A Anderson, Igor Radzikh, Jillian V Kodger, Akshay S Patil, Morgan Staton, Anny Mulya, Genevieve M Crane, Silvio Litovsky, Yana Sandlers and 1 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in Research square, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

11 authors.

Usua OyarbideDepartments of Pediatrics and Cancer Biology, Lerner Research Institute and Cleveland Clinic, Cleveland, OH.
Rebecca A AndersonDepartments of Pediatrics and Cancer Biology, Lerner Research Institute and Cleveland Clinic, Cleveland, OH.
Igor RadzikhDepartment of Chemistry, Cleveland State University, Cleveland, OH.
Jillian V KodgerDepartment of Chemistry, Cleveland State University, Cleveland, OH.
Akshay S PatilDepartment of Chemistry, Cleveland State University, Cleveland, OH.
Morgan StatonDepartments of Pediatrics and Cancer Biology, Lerner Research Institute and Cleveland Clinic, Cleveland, OH.
Anny MulyaDepartment of Inflammation and Immunity, Lerner Research Institute and Cleveland Clinic, Cleveland, OH.
Genevieve M CraneDepartment of Pathology and Laboratory Medicine, Cleveland Clinic, Cleveland, Ohio, USA.
Silvio LitovskyDivision of Anatomic Pathology, Department of Pathology, University of Alabama at Birmingham, Birmingham, AL.
Yana SandlersDepartment of Chemistry, Cleveland State University, Cleveland, OH.
Seth J CoreyDepartments of Pediatrics and Cancer Biology, Lerner Research Institute and Cleveland Clinic, Cleveland, OH.

Funding

Clinical and Translational Science Collaborative of Northern Ohio, Catalyzing Linkages to Equity in Health (CLE Health)UM1TR004528 · NCATS · CASE WESTERN RESERVE UNIVERSITY · PI GRACE A MCCOMSEY · 2023 to 2026
$32.1M
NRSA Training CoreTL1TR002549 · NCATS · CASE WESTERN RESERVE UNIVERSITY · PI HARDING, CLIFFORD V · 2018 to 2022
$2.9M
Genetic Dissection of Stress Responses in Shwachman-Diamond SyndromeR01DK132812 · NIDDK · CLEVELAND CLINIC LERNER COM-CWRU · PI COREY, SETH JOEL · 2023 to 2025
$701k
NCATS NIH HHS TL1 TR002549NCATS NIH HHS UM1 TR004528NIDDK NIH HHS R01 DK132812
6 · The paper itself

Abstract

Barth syndrome is an X-linked syndrome characterized by cardiomyopathy, skeletal myopathy, and neutropenia. This life-threatening disorder results from loss-of-function mutations in

Identifiers

PMID40313767
PMCPMC12045452

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.