Evidence map›Paper›PMID 40313653›Full record

ArticleEJHaem2025

Safe and Efficacious Use of Low-Dose Rituximab in Postpubertal Paediatric Patients With Immune Thrombocytopenia.

Jennifer Darlow, Gerard Gurumurthy, Nathan Jeffreys, Lianna Reynolds, Vismay Deshani, John Grainger

Abstract read
In one paragraph

Article in EJHaem, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Jennifer DarlowRoyal Manchester Children's Hospital Manchester UK.
Gerard GurumurthyUniversity of Manchester Manchester UK.ORCID https://orcid.org/0009-0008-0808-8779
Nathan JeffreysRoyal Manchester Children's Hospital Manchester UK.
Lianna ReynoldsRoyal Manchester Children's Hospital Manchester UK.
Vismay DeshaniRoyal Manchester Children's Hospital Manchester UK.
John GraingerRoyal Manchester Children's Hospital Manchester UK.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Rituximab, a CD20 monoclonal antibody, is used in chronic/refractory immune thrombocytopenia (ITP). Standard dosing is 375 mg/m Methods: Patients treated with 100 mg weekly Rituximab for 4 weeks alongside dexamethasone at 10 mg/m Results: Of the 10 patients treated, six responded completely, one partially and three showed no response. Four responders maintained their response over 2 years. One Rituximab-related infusion reaction and one Dexamethasone-related adverse event were reported. Conclusion: Rituximab 100 mg weekly may be non-inferior to 375 mg/m

Identifiers

PMID40313653
PMCPMC12044411

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.