Evidence map›Paper›PMID 40313647›Full record

ArticleComplex psychiatry

Caffeine Consumption, Psychological Distress, and Insomnia in a Cohort of Individuals with Depression.

Harry A McIntosh, Aleah J Borgas, Nisreen Aouira, Brittany L Mitchell, Jacob J Crouse, Sarah E Medland, Ian B Hickie, Naomi R Wray, Nicholas G Martin, Christel M Middeldorp and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Complex psychiatry. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Harry A McIntoshChild Health Research Centre, The University of Queensland, Brisbane, QLD, Australia.
Aleah J BorgasSchool of Psychology, The University of Queensland, Brisbane, QLD, Australia.
Nisreen AouiraChild Health Research Centre, The University of Queensland, Brisbane, QLD, Australia.
Brittany L MitchellQIMR Berghofer Medical Research Institute, Brisbane, QLD, Australia.
Jacob J CrouseYouth Mental Health and Technology Team, Brain and Mind Centre, The University of Sydney, Sydney, NSW, Australia.
Sarah E MedlandQIMR Berghofer Medical Research Institute, Brisbane, QLD, Australia.
Ian B HickieYouth Mental Health and Technology Team, Brain and Mind Centre, The University of Sydney, Sydney, NSW, Australia.
Naomi R WrayInstitute of Molecular Bioscience, The University of Queensland, Brisbane, QLD, Australia.
Nicholas G MartinQIMR Berghofer Medical Research Institute, Brisbane, QLD, Australia.
Christel M MiddeldorpChild Health Research Centre, The University of Queensland, Brisbane, QLD, Australia.
Enda M ByrneChild Health Research Centre, The University of Queensland, Brisbane, QLD, Australia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: Caffeine is a widely consumed psychoactive compound that can cause anxiety and sleep difficulties, in part due to genetic variation. We investigated the association between caffeine consumption, psychological distress, and sleep difficulties in a genetically informative cohort of individuals with a history of depression. Methods: Survey data and genetic information were sourced from the Australian Genetics of Depression Study (AGDS [ Results: The highest consumers of caffeine reported higher psychological distress measured by the Kessler 10 scale (β = 1.21, SE = 0.25, Conclusions: Higher rates of caffeine consumption were associated with higher levels of psychological distress, but not insomnia, in individuals with a history of depression. While the direction of causality is unclear, caffeine consumption may be a modifiable factor to reduce distress in individuals susceptible to mental health problems. Some of the previous findings of common variant associations with caffeine consumption and susceptibility were replicated.

Indexed as

ADORA2AAHRCaffeineCYP1A1CYP1A2InsomniaPsychiatric disorders

Identifiers

PMID40313647
PMCPMC12043281

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.