Evidence map›Paper›PMID 40313598›Full record

ArticleFrontiers in genetics2025

Correlation between gene polymorphisms and perioperative analgesia in patients undergoing gynecological surgery.

Meng Cai, Xiaofeng Lei, Lin Gan, Jing Li, Jin Yu

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Article in Frontiers in genetics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

5 authors.

Meng CaiDepartment of Anesthesiology, Chongqing Health Center for Women and Children; Women and Children's Hospital of Chongqing Medical University, Chongqing, China.
Xiaofeng LeiDepartment of Anesthesiology, Chongqing Health Center for Women and Children; Women and Children's Hospital of Chongqing Medical University, Chongqing, China.
Lin GanDepartment of Anesthesiology, Chongqing Health Center for Women and Children; Women and Children's Hospital of Chongqing Medical University, Chongqing, China.
Jing LiDepartment of Anesthesiology, Chongqing Health Center for Women and Children; Women and Children's Hospital of Chongqing Medical University, Chongqing, China.
Jin YuDepartment of Anesthesiology, Chongqing Health Center for Women and Children; Women and Children's Hospital of Chongqing Medical University, Chongqing, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Objectives: This study aims to identify specific single nucleotide polymorphism (SNP) correlated to perioperative analgesia in patients undergoing laparoscopic gynecological surgery. Methods: A total of 200 females meeting specific criteria underwent gynecological laparoscopic procedures under general anesthesia. Preoperative pain sensitivity was evaluated using Pain Sensitivity Questionnaire and Pain Catastrophizing Scale (PCS). Venous blood samples were collected for SNP analysis of nine genes. The study analyzed the correlation between SNPs and pre-operative pain assessment, analgesics usage, and the occurrence of related adverse effects. Results: Six out of nine identified loci showed polymorphisms. The PCS scores were higher in the mutation group (GG + GC) for Conclusion: Patients with GG and AG genotypes of

Indexed as

gynecological laparoscopic operationpersonalized medicinepharmacogenomicspostoperative analgesiasingle nucleotide polymorphism

Identifiers

PMID40313598
PMCPMC12043472

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