SynthesisFrontiers in cardiovascular medicine2025
Association between polychlorinated biphenyls and hypertension risk: a systematic review and meta-analysis.
Synthesis in Frontiers in cardiovascular medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Editorial: Environmental determinants of cardiovascular health: interactions with lifestyle and socioeconomic factors.Frontiers in cardiovascular medicine · 2026Article
Corrections and comments
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Authors and funding
12 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background and Aim: Hypertension (HTN) is a widespread global health challenge, and its increasing prevalence is attributed to individual and environmental risk factors. Persistent organic pollutants (POPs), especially polychlorinated biphenyls (PCBs), contribute to cardiovascular risk by accumulating in fatty tissues, which leads to oxidative stress and vascular inflammation. This review and meta-analysis aimed to investigate the association between PCB exposure and hypertension. Methods: Adhering to the PRISMA 2020 guidelines, data sources such as PubMed, Scopus, Web of Science, and Google Scholar were systematically searched up to July 2024 to find observational studies on the link between PCBs and hypertension risk. Studies were reviewed and chosen according to established inclusion and exclusion criteria, focusing on observational studies examining PCB exposure and hypertension risk. Independent reviewers conducted data extraction, and the quality of studies was evaluated using the JBI critical appraisal tool. A meta-analysis with a random-effects model was conducted to determine combined odds ratios (ORs) for hypertension linked to total PCB exposure and specific PCB types. Results: Of the 494 records identified, 21 studies met the inclusion criteria, comprising 5 cohort studies, 15 cross-sectional studies, and one case-control study, totaling 51,514 participants. Exposure to total PCBs correlated with an elevated risk of hypertension (OR = 1.78, 95% CI: 1.30-2.44). Dioxin-like PCBs were also associated with a heightened risk (OR = 1.54, 95% CI: 1.24-1.90), while non-dioxin-like PCBs were not significantly linked (OR = 1.16, 95% CI: 0.81-1.66). Among individual congeners, PCB-74, PCB-118, PCB-105, and PCB-153 were significantly related to higher hypertension risk. Conclusion: These findings indicate a positive correlation between PCB exposure and hypertension, particularly with dioxin-like PCBs and certain PCB congeners. Additional research is necessary to clarify the mechanisms involved and to promote measures for reducing PCB exposure, particularly in high-risk populations. Systematic Review Registration: https://www.crd.york.ac.uk/prospero/display_record.php?ID=CRD42024595223, PROSPERO (CRD42024595223).
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.