ArticleFrontiers in toxicology2025
Developing a predictive model for blood-brain-barrier permeability to explore relevance of
Article in Frontiers in toxicology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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Who cites it
3 citing papers in PubMed.
- Article
- Towards learning and memory risk assessment with human brain organoids: barriers and opportunities.Frontiers in toxicology · 2026Review
- Informing development of brain cancer therapies within "preclinical trials" using ex vivo patient tumors.Advanced drug delivery reviews · 2026Review
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Authors and funding
4 authors.
Funding
Abstract
Introduction: Despite recent rapid advancements in Methods: We collected permeability data from parallel artificial membrane permeability assays for brain membranes (PAMPA-BBB) for 106 compounds with varied physicochemical properties. This was utilized to develop an empirical model to expand the potential coverage of chemicals. A list of 23 chemicals with available Results: The PAMPA-BBB predictive model showed promising results, with an R2 of 0.71 (measured vs predicted permeabilities). Considering permeability did not improve the correlation between Discussion: This weak correlation may stem from model uncertainty and the exclusion of other toxicokinetic processes, along with interspecies toxicodynamics differences. Our results indicate more detailed information on how neurotoxic substances behave inside the body is essential to better utilize the
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