ArticleFrontiers in public health2025
Exposure to polycyclic aromatic hydrocarbons and bone mineral density in children and adolescents: results from the 2011-2016 National Health and Nutrition Examination Survey.
Article in Frontiers in public health, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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2 citing papers in PubMed.
- Article
- Polycyclic aromatic hydrocarbon derivative 3-hydroxybenz[a]anthracene promotes the progression of T47D breast cancer cells by modulating relevant protein expression.Frontiers in cell and developmental biology · 2026Article
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4 authors.
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Abstract
Introduction: Identifying factors that hinder bone development in children and adolescents is crucial for preventing osteoporosis. Exposure to polycyclic aromatic hydrocarbons (PAHs) has been linked to reduced bone mineral density (BMD), although available data, especially in children and adolescents, are limited. We examined the associations between urinary hydroxylated-PAHs (OH-PAHs) and lumbar spine BMD, pelvic BMD, and total BMD among 8-19 years participants ( Methods: Weighted linear regressions were employed to assess the associations between urinary OH-PAHs and BMD. Additionally, Bayesian kernel machine regression (BKMR) and quantile g-computation (Qgcomp) models were utilized to investigate the effect of co-exposure of PAHs on BMD. Results: Several urinary OH-PAHs exhibited negative associations with lumbar spine BMD, pelvic BMD, and total BMD in children and adolescents. For instance, an increase of one unit in the natural log-transformed levels of urinary 1-hydroxypyrene and 2&3-Hydroxyphenanthrene was linked with a decrease of -0.014 g/cm Conclusion: Our findings revealed that exposure to PAHs might hinder bone development in children and adolescents, potentially impacting peak bone mass-an essential factor influencing lifelong skeletal health.
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