ArticleCureus2025
Antidepressant Use in New-Onset Depression After Total Joint Arthroplasty Is Not Associated With Reduced Arthroplasty-Related Complications.
Article in Cureus, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background and objective Some patients without pre-existing depression develop new-onset depression (NOD) following total joint arthroplasty (TJA), potentially impacting recovery and quality of life. New-onset depression has been associated with increased TJA complications (i.e., periprosthetic fracture, prosthetic joint infection, and revision), but the role of antidepressants in this population remains unexplored. This paper assessed the prevalence of antidepressant use in TJA patients with NOD and its association with postoperative complications. Methods We conducted a retrospective cohort study using a national database (2010-2022). Primary TJA patients aged ≥18 years with osteoarthritis and NOD within six months were included, while those with preoperative depression, antidepressant use, or < one-year follow-up were excluded. Study groups comprised those on antidepressants; controls consisted of those not on antidepressants. Logistic regressions adjusting for age, sex, and comorbidities assessed the odds of one-year postoperative complications. Results Among TJA patients with NOD, 25.3% (n=1,735) of total hip arthroplasty (THA) and 27.6% (n=4,365) of total knee arthroplasty (TKA) patients used antidepressants. Total hip arthroplasty patients on antidepressants had 1.70 times higher odds of periprosthetic fracture (95% CI: 1.22, 2.36) but showed no significant differences in prosthetic joint infection or revision. No significant differences were found in the TKA group. Conclusions Antidepressant use in NOD was not associated with reduced arthroplasty-related complications; however, treating depressive symptoms may still aid recovery. Further research, incorporating patient-level data on depression severity, therapy, and social support, antidepressant subclassification, and medication dosing and duration, is needed to identify which patients benefit from antidepressants and optimize postoperative mental health management.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.