ArticleFrontiers in microbiology2025
Ceftolozane/tazobactam use and emergence of resistance: a 4-year analysis of antimicrobial susceptibility in
Article in Frontiers in microbiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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Who cites it
3 citing papers in PubMed.
- Metallo-β-lactamase-producingFrontiers in microbiology · 2026Review
- TargetingAntimicrobial agents and chemotherapy · 2025Article
- Antibiotic stewardship: what for?Frontiers in antibiotics · 2025Article
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Authors and funding
13 authors.
Funding
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Abstract
Background: Ceftolozane/tazobactam (C/T) was temporarily withdrawn from December 2020 to February 2022: this forced unavailability created the conditions to study how drug discontinuation might influence Methods: Clinically relevant PA isolates collected between January 1st 2019 and February 22nd 2023 with a C/T susceptibility test available were included. Changes in PA antibiotic susceptibility towards C/T and other antibiotics were examined in three different periods (period A, March-December 2019 and March-December 2020, C/T available; period B, March-December 2021, C/T withdrawn; period C, March-December 2022, C/T reintroduced), also considering the overall consumption rate through the Defined Daily Dose per 100 bed-days per year. Results: Seven hundred and fifty-one PA isolates were included. A statistically significant reduction of C/T resistance rate was observed when C/T became unavailable, followed by a subsequent increase with its reintroduction (period A 25.1% vs. period B 5.3% vs. period C 10.0%, Conclusion: The unavailability of C/T created the conditions to analyze the practical application of the theory of fitness cost to maintain resistance. A subsequent increase after a first reduction in C/T resistance rate was observed, probably due to persistence of resistant isolates and antibiotic selective pressure. Continuous monitoring of antibiotic use and evolving resistance is essential.
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