Evidence map›Paper›PMID 40313384›Full record

ArticlePeerJ2025

Effects of bortezomib on intracellular antioxidant and apoptosis in HepG2cells.

Grażyna Świderska-Kołacz, Magdalena Madej, Szymon Zmorzynski, Wojciech Styk, Iwona Surowiec, Bożena Witek, Anna Wojciechowska, Joanna Czerwik-Marcinkowska, Anna Nowakowska

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in PeerJ, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Dissecting Complex Interactions Between Ferroptosis and the Proteasome.bioRxiv : the preprint server for biology · 2026
    Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Grażyna Świderska-KołaczInstitute of Biology, Jan Kochanowski University, Kielce, Poland.
Magdalena MadejInstitute of Biology, Jan Kochanowski University, Kielce, Poland.
Szymon ZmorzynskiInstitute of Human Sciences, Academy of Zamość, Zamość, Poland.
Wojciech StykAcademic Laboratory of Psychological Tests, Medical University of Lublin, Lublin, Poland.
Iwona SurowiecInstitute of Biology, Jan Kochanowski University, Kielce, Poland.
Bożena WitekInstitute of Biology, Jan Kochanowski University, Kielce, Poland.
Anna WojciechowskaDepartment of Geobotany and Landscape Planning, Nicolaus Copernicus University of Torun, Toruń, Poland.
Joanna Czerwik-MarcinkowskaInstitute of Biology, Jan Kochanowski University, Kielce, Poland.
Anna NowakowskaDepartment of Animal Physiology and Neurobiology, Nicolaus Copernicus University of Torun, Toruń, Poland.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Bortezomib, as a proteasome inhibitor, is used in clinical trials related to solid cancers. However, its use is not always associated with a good response to treatment. Taking into account the above, we decided to analyze the effect of the time-dependency (24

Indexed as

Antineoplastic AgentsAntioxidantsApoptosisBortezomibCatalaseDose-Response Relationship, DrugGlutathioneGlutathione PeroxidaseGlutathione ReductaseHep G2 CellsHumansMalondialdehydeOxidative StressSuperoxide DismutaseAntineoplastic AgentsAntioxidantsBortezomibCatalaseGlutathioneGlutathione PeroxidaseGlutathione ReductaseMalondialdehydeSuperoxide DismutaseApoptosisBortezomibHepG2 cellsOxidative stress

Identifiers

PMID40313384
PMCPMC12045286

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.