ArticleNeuropsychiatric disease and treatment2025
Impact of Emotional Blunting on Patient Social Function and Depressive Symptoms: A Post Hoc Analysis of a Web-Based Survey in Japanese Patients with Major Depressive Disorder.
Article in Neuropsychiatric disease and treatment, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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2 citing papers in PubMed.
- Emotional Blunting During Antidepressant Treatment: Implications for Clinical Decision-Making and Patient-Centred Care.Journal of evaluation in clinical practice · 2026Review
- Emotional Blunting in Hong Kong Patients with Major Depressive Disorder Treated with Vortioxetine: A Naturalistic Observational Study.Biomedicines · 2026Article
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6 authors.
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Abstract
Background: Emotional blunting (EB), defined as a flattening of emotions and emotional indifference, is reported by many patients with major depressive disorder (MDD) taking antidepressants. Severity of EB correlates with depressive symptoms, as well as deficits in social function, anxiety and health-related quality of life. However, awareness and understanding of EB and its impact on treatment of MDD remain poorly understood. Methods: This was a post hoc analysis of data from a web-based survey of 3376 adults with MDD in Japan. The primary endpoint was the correlation between total and subdomain scores of the Oxford Depression Questionnaire (ODQ; a validated instrument to assess EB) and total and individual domain/item scores of the Work and Social Adjustment Scale (WSAS) and Patient Health Questionnaire 9-item (PHQ-9). The secondary endpoint explored which patients had a discrepancy between EB symptoms (assessed by the ODQ) and their own evaluation of EB (using a validated screening question). Results: There was a moderate correlation between the ODQ total score and the WSAS total score (Spearman's rank correlation coefficient [ Conclusion: The ODQ subdomains of NC and PR are important factors when evaluating the impact of EB on social function and severity of depressive symptoms in patients with MDD. Physicians should assess EB symptoms for each patient, considering the patient's background.
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