ArticlemedRxiv : the preprint server for health sciences2025
Timing-dependent synergies between noninvasive motor cortex and spinal cord stimulation in chronic cervical spinal cord injury.
Article in medRxiv : the preprint server for health sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07539025 (Paired Non-invasive Stimulation of Hand Motor Cortex and Median Nerve to Induce Plasticity in the Cervical Spinal Cord), which is not on this map. Not yet cited in PubMed.
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Paired Non-invasive Stimulation of Hand Motor Cortex and Median Nerve to Induce Plasticity in the Cervical Spinal Cord
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12 authors.
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Abstract
Precise movement requires integrating descending motor control with sensory feedback. Sensory networks interact strongly with descending motor circuits within the spinal cord. We targeted this interaction by pairing stimulation of the motor cortex with coordinated stimulation of the cervical spinal cord. We used separate non-invasive and epidural experiments to test the hypothesis that the strongest muscle response would occur when paired brain and spinal cord stimuli simultaneously converge within the spinal cord. For non-invasive experiments, we measured arm and hand muscle motor evoked potentials (MEPs) in response to transcranial magnetic stimulation (TMS) and transcutaneous spinal cord stimulation (TSCS) in 16 individuals with chronic spinal cord injury (SCI) and 15 uninjured individuals. We compared this noninvasive approach to intraoperative paired stimulation experiments using dorsal epidural electrodes in 38 individuals undergoing surgery for cervical myelopathy. We observed augmented muscle responses to suprathreshold TMS when subthreshold TSCS stimuli were timed to converge synchronously in the spinal cord. At convergent timing, target muscle MEPs increased by 11.0% overall (13.3% in people with SCI, 6.2% in uninjured individuals) compared to non-convergent time intervals. Facilitation correlated with TSCS intensity, with intensity close to movement threshold being most effective. Facilitation did not correlate with SCI level or severity, indicating spared circuits were sufficient for this effect. Noninvasive pairing produced less facilitation compared to intraoperative (epidural) pairing. Thus, sensorimotor interactions in the cervical spinal spinal cord can be targeted with paired stimulation in health and after SCI.
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