Evidence map›Paper›PMID 40313282›Full record

ArticlemedRxiv : the preprint server for health sciences2025

The gSOS Polygenic Score is Associated with Bone Density and Fracture Risk in Childhood.

Jonathan A Mitchell, Jonathan Bradfield, Shana E McCormack, Alessandra Chesi, Heidi J Kalkwarf, Joan M Lappe, Sharon E Oberfield, Dana L Duren, John A Shepherd, Kurt D Hankenson and 4 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in medRxiv : the preprint server for health sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

14 authors.

Jonathan A MitchellDivision of Gastroenterology, Hepatology and Nutrition, The Children's Hospital of Philadelphia, Philadelphia.
Jonathan BradfieldQuantinuum Research LLC, Wayne, PA, USA.
Shana E McCormackDepartment of Pediatrics, Perelman School of Medicine, University of Pennsylvania, Philadelphia.
Alessandra ChesiCenter for Spatial and Functional Genomics, Children's Hospital of Philadelphia, Philadelphia, PA.
Heidi J KalkwarfDivision of Gastroenterology, Hepatology and Nutrition, Cincinnati Children's Hospital Medical Center, Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH.
Joan M LappeDivision of Endocrinology, Department of Medicine, Creighton University, Omaha.
Sharon E OberfieldDivision of Pediatric Endocrinology, Diabetes, and Metabolism, Department of Pediatrics, Columbia University Medical Center, New York.
Dana L DurenDepartment of Orthopedics, University of Missouri, Columbia, MO.
John A ShepherdCancer Center, University of Hawaii, Honolulu, HI.
Kurt D HankensonDepartment of Orthopedic Surgery, University of Michigan, Ann Arbor, MI.
Andrea KellyDepartment of Pediatrics, Perelman School of Medicine, University of Pennsylvania, Philadelphia.
Hakon HakonarsonDepartment of Pediatrics, Perelman School of Medicine, University of Pennsylvania, Philadelphia.
Struan F A GrantDepartment of Pediatrics, Perelman School of Medicine, University of Pennsylvania, Philadelphia.ORCID 0000-0003-2025-5302
Babette S ZemelDivision of Gastroenterology, Hepatology and Nutrition, The Children's Hospital of Philadelphia, Philadelphia.

Funding

Cincinnati Center for Clinical and Translational Sciences and TrainingUL1TR000077 · NCATS · UNIVERSITY OF CINCINNATI · PI HEUBI, JAMES E., TSEVAT, JOEL · 2012 to 2014
$9.9M
Genomics of bone and body composition traits in childrenR01HD100406 · NICHD · CHILDREN'S HOSP OF PHILADELPHIA · PI GRANT, STRUAN F A, ZEMEL, BABETTE S · 2020 to 2024
$3.4M
Genome Wide Association Study of Bone Mineral Accretion During ChildhoodR01HD058886 · NICHD · CHILDREN'S HOSP OF PHILADELPHIA · PI GRANT, STRUAN F A, ZEMEL, BABETTE S · 2010 to 2013
$3.1M
NCATS NIH HHS UL1 TR000077NICHD NIH HHS R01 HD058886NICHD NIH HHS R01 HD100406
6 · The paper itself

Abstract

The polygenic risk score

Identifiers

PMID40313282
PMCPMC12045425

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.