ArticleEuropean journal of neurology2025
Identifying Mild Behavioral and Neurocognitive Impairment in Amyotrophic Lateral Sclerosis (MBNI-ALS) Provides Key Prognostic Insights.
Article in European journal of neurology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 2 of them syntheses that pooled it.
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Who cites it
12 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Cognitive decline over time in myotonic dystrophy type 1: a systematic review of longitudinal studies.Frontiers in neurology · 2026Pooled it
- A comparative meta-analysis of seven types of exercise-based physical therapy for gait stabilization, fall risk, and postural control in Parkinson's disease patients.Frontiers in neurology · 2025Pooled it
- Neuropsychological Sub-Phenotypes in Amyotrophic Lateral Sclerosis.European journal of neurology · 2026Article
- Exploring the Lived Experiences of Individuals with Amyotrophic Lateral Sclerosis (ALS): A Qualitative Study and Conceptual Model of Signs, Symptoms, and Functional Impacts.Neurology and therapy · 2026Article
- Elucidating the Neurobiological Underpinnings of Mild Behavioral Impairment in Tauopathies: Clinical and Molecular Insights.International journal of molecular sciences · 2026Review
- Tui Na Acupressure Modulates Treg Immunosuppression via FoxP3/mTORC1 Signalling in ALS Mice.Immunology · 2026Article
- Article
- Analysis of factors influencing sleep disorders in patients with amyotrophic lateral sclerosis.Scientific reports · 2025Article
- Phenotyping and characterising gait profiles of people with multiple sclerosis.Scientific reports · 2025Article
- Exploratory analysis of smartphone-based step counts as a digital biomarker for survival in ALS patients.Frontiers in digital health · 2025Article
- Three-dimensional gait analysis in spinal disorders: biomechanical insights and clinical applications for diagnosis, surgical planning, and rehabilitation.Frontiers in neurology · 2025Review
- Brain connectivity moderated the effects of cognitive intraindividual variability on mobility in cognitively frail older adults.Frontiers in aging neuroscience · 2025Article
Corrections and comments
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Authors and funding
9 authors.
Funding
Abstract
backgroundAmyotrophic lateral sclerosis (ALS) is a multisystem neurodegenerative disease encompassing cognitive and behavioral impairments. The Revised Diagnostic Criteria for ALS-frontotemporal spectrum disorder (ALS-FTDS), while widely adopted, may overlook subtle impairments such as memory and visuospatial deficits, limiting their prognostic value.
objectivesThis study aimed to apply the Mild Behavioral and Neurocognitive Impairment (MBNI) approach, adapted from other neurodegenerative diseases, to ALS patients and assess its prognostic utility for survival and disease progression.
methodsA prospective cohort of 201 ALS patients was evaluated between January 2018 and July 2024. Participants underwent comprehensive cognitive and behavioral assessments. The MBNI approach identified patients with mild cognitive impairment (MCI), mild behavioral impairment (MBI), or combined cognitive-behavioral impairment (MCBI). Prognostic value was analyzed using Kaplan-Meier survival curves, Cox proportional hazards models, and logistic regression for disease progression.
resultsMild cognitive and/or behavioral impairments were detected in 67% of patients classified as cognitively normal by ALS-FTDS criteria. At a median follow-up of 15 months, these patients showed shorter tracheostomy-free survival (all p < 0.005). MCI (HR5.3; CI 1.10-25.41; p = 0.038) and frontotemporal dementia (HR6.2; Confidence Interval: 1.34-28.40; p = 0.019) independently predicted poor outcomes. Logistic regression confirmed that MCBI and frontotemporal dementia were associated with rapid progression (both p < 0.019).
conclusionThe MBNI approach enhances the detection of mild cognitive and behavioral impairments in ALS, providing prognostic insights and improving stratification over the Revised Diagnostic Criteria for ALS-FTDS. This framework supports personalized care and the design of clinical trials targeting early disease stages.
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