Evidence map›Paper›PMID 40312723›Full record

ArticleBMC veterinary research2025

Maternal supplementation of Lonicera flos and Scutellaria Baicalensis mixed extracts improve reproduction performance and metabolic health through modulating gut microbiota during pregnancy.

Mu Wang, Shengnan Yin, Jinghua Cheng, Yuqiang Guo, Huiyuan Lv, Siwen Jiang, Jian Peng, Yuanfei Zhou

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC veterinary research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Frontiers in veterinary science · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Mu WangCollege of Animal Science and Technology, Huazhong Agricultural University, Wuhan, 430070, China.
Shengnan YinCollege of Animal Science and Technology, Huazhong Agricultural University, Wuhan, 430070, China.
Jinghua ChengCollege of Animal Science and Technology, Huazhong Agricultural University, Wuhan, 430070, China.
Yuqiang GuoTecon Biology Co., Ltd, Urumqi, 830011, China.
Huiyuan LvBeijing Centre Biology Co., Ltd, Beijing, 102600, China.
Siwen JiangCollege of Animal Science and Technology, Huazhong Agricultural University, Wuhan, 430070, China.
Jian PengCollege of Animal Science and Technology, Huazhong Agricultural University, Wuhan, 430070, China. pengjian@mail.hzau.edu.cn.
Yuanfei ZhouCollege of Animal Science and Technology, Huazhong Agricultural University, Wuhan, 430070, China. zhouyuanfei@mail.hzau.edu.cn.

Funding

National Key Research and Development Program of China 2021YFD1300401National Key Research and Development Program of China 2024YFD1300701
6 · The paper itself

Abstract

backgroundThis study aimed to evaluate the impacts of dietary supplementation with a combination of plant extracts on performance, metabolic health, and gut microbiota of sows. A total of 1003 crossbred pregnancy sows (DanBred Landrace × DanBred Yorkshire, mean parity 4.44 ± 1.84) were assigned to one of the two dietary treatments: a control group (CON, basal diet) and a Lonicera flos and Scutellaria baicalensis mixed extracts group (LSE, basal diet supplemented with 0.5 g/kg of mixed extracts).

resultsSupplementation of LSE increased (P < 0.05) the numbers of total born, litter weight and average piglet weight on L21 d, average daily feed intake, and survival rate of piglets during lactation. Compared to CON, LSE group reduced (P < 0.05) interleukin-6 (IL-6) concentration in the feces and plasma on G109 d, while increased (P < 0.05) interleukin-10 (IL-10) concentration on G109 d and on L3 d. Supplementation of LSE had lower (P < 0.05) plasma reactive oxygen species levels on G30 d and on L3 d, and had a reducing tendency (P = 0.07) for thiobarbituric acid reactive substances concentrations and a trend toward increased (P = 0.08) value of homeostatic model assessment of insulin sensitivity of sow plasma on G109 d. In addition, supplementation of LSE increased (P < 0.05) the abundance of Firmicutes and Proteobacteria and decreased (P < 0.05) the abundance of Bacteroidetes and Spirochaetes on G109 d. The abundance of Christensenellaceae_R_7_group, UCG_002, Clostridium_sensu_stricto_1, Escherichia_Shigella, un_f__Christensenellaceae, Bacteroides, and Terrisporobacter were significantly increased (P < 0.05) in the LSE diet group. The abundance of Christensenellaceae_R_7_group, UCG_002 and un_f__Ruminococcaceae were positively correlated with plasma IL-10 (P < 0.01), and negatively correlated with plasma IL-6 and TBARS levels.

conclusionsThis study demonstrates that dietary supplementation with Lonicera flos and Scutellaria baicalensis mixed extracts (LSE) at 0.5 g/kg during gestation significantly improves reproductive performance and metabolic health in sows, likely through modulating gut microbiota composition.The observed improvements in performance and health parameters coincide with microbiota-driven inflammation attenuation and redox balance restoration, suggesting a gut-immune axis regulatory role of LSE.

Indexed as

Gastrointestinal MicrobiomeLoniceraPlant ExtractsReproductionScutellaria baicalensisAnimal FeedAnimalsDietDietary SupplementsFemalePregnancySwinePlant ExtractsScutellaria baicalensis extractGut microbiotaInflammation and stress indicatorsPlant extractsReproductive performanceSow

Identifiers

PMID40312723
PMCPMC12044769

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LicenceCC BY-NC-ND
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.