Trial reportBMC complementary medicine and therapies2025
The effect of aromatherapy intervention with Bergamot and Grapefruit essential oils on premenstrual syndrome and menstrual symptoms: a randomized controlled trial.
Trial report in BMC complementary medicine and therapies, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06289764 (The Effect of Aromatherapy Application With Bergamot and Grapefruit Essential Oils on Premenstrual Syndrome and Menstrual Symptoms), which is not on this map. Cited by 3 papers, 1 of them a synthesis that pooled it.
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The trial behind it
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The Effect of Aromatherapy Application With Bergamot and Grapefruit Essential Oils on Premenstrual Syndrome and Menstrual Symptoms
Who cites it
3 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Self-management strategies for menstrual cycle symptoms: a systematic review.BMC women's health · 2026Pooled it
- Peppermint oil in menstrual disorders and menopausal symptoms: a research progress review.Frontiers in endocrinology · 2026Review
- Prevalence of premenstrual syndrome, premenstrual dysphoric disorder, and dysmenorrhea in nursing students: a systematic review, meta-analysis, and evidence-based recommendations.Frontiers in global women's health · 2025Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundPremenstrual syndrome and menstrual symptoms adversely affect approximately 80-95% of women of reproductive age. Aromatherapy interventions are used to reduce premenstrual syndrome and menstrual symptoms. This study was conducted to determine the effect of aromatherapy intervention with bergamot and grapefruit essential oils on premenstrual syndrome and menstrual symptoms.
methodsNinety women with premenstrual syndrome were included the study. Participants were randomly divided into 3 groups: Bergamot(n = 30), Grapefruit(n = 30), Placebo(n = 30). Participants in each group were made to smell pure essential oil for 30 min 3 times a day for 4 days during the luteal phase of the menstrual cycle. The used was repeated in 3 menstrual cycles. "Premenstrual Syndrome Scale (PMSS)" was used to evaluate premenstrual syndrome and "Menstrual Symptom Questionnaire (MSQ)" was used to evaluate menstrual symptoms. All measurements were performed before and after the study.
resultsThe results showed that grapefruit essential oil was effective in reducing PMSS total score (p = 0.010) and sub-scale scores (depressive affect, anxiety, fatigue, depressive thoughts, appetite changes, sleep changes and bloating (p < 0.001), irritability (p = 0.024), pain (p = 0.047)). Although grapefruit essential oil had no effect on the total score of the MSQ. Grapefruit essential oil was found to be effective in reducing the MSQ scale sub-scale scores (menstrual pain symptoms (p = 0.024) and the use of coping methods with menstrual pain (p = 0.011)). Bergamot essential oil was found to be effective in reducing PMSS total score (p = 0.001) and PMSS sub-scale scores depressive affect (p = 0.013), irritability (p = 0.034), depressive thoughts and appetite changes (p = 0.026), pain (p = 0.001)). In addition, there was no effect on the menstrual syndrome scale and its sub-dimensions (p > 0.05).
conclusionGrapefruit essential oil was effective in reducing both premenstrual syndrome and menstrual symptoms, whereas bergamot essential oil was only effective in reducing premenstrual symptoms. TRIAL REGISTRATION NUMBER: NCT06289764 (2024-02-01).
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