Evidence map›Paper›PMID 40312602›Full record

ReviewBiological trace element research2025

Do Ternary DNA-Cr(III)-Small Molecule Adducts Form?

Sydney Marchi, Katie Repke, Gracie Sunde, Emily Wilkes, Kaleb Kovitch, Riann McMillan, Dontarie Stallings, John B Vincent, Stephen A Woski

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Biological trace element research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Sydney MarchiDepartment of Chemistry and Biochemistry, The University of Alabama, Tuscaloosa, AL, 35487-0336, USA.
Katie RepkeDepartment of Chemistry and Biochemistry, The University of Alabama, Tuscaloosa, AL, 35487-0336, USA.
Gracie SundeDepartment of Chemistry and Biochemistry, The University of Alabama, Tuscaloosa, AL, 35487-0336, USA.
Emily WilkesDepartment of Chemistry and Biochemistry, The University of Alabama, Tuscaloosa, AL, 35487-0336, USA.
Kaleb KovitchDepartment of Chemistry and Biochemistry, The University of Alabama, Tuscaloosa, AL, 35487-0336, USA.
Riann McMillanDepartment of Chemistry and Biochemistry, The University of Alabama, Tuscaloosa, AL, 35487-0336, USA.
Dontarie StallingsDepartment of Chemistry and Biochemistry, The University of Alabama, Tuscaloosa, AL, 35487-0336, USA.
John B VincentDepartment of Chemistry and Biochemistry, The University of Alabama, Tuscaloosa, AL, 35487-0336, USA.
Stephen A WoskiDepartment of Chemistry and Biochemistry, The University of Alabama, Tuscaloosa, AL, 35487-0336, USA. swoski@ua.edu.

Funding

Molecular Structure of Chromium-DNA AdductsR15ES033800 · NIEHS · UNIVERSITY OF ALABAMA IN TUSCALOOSA · PI VINCENT, JOHN BERTRAM, WISE, JOHN PIERCE · 2022 to 2022
$434k
NIEHS NIH HHS R15 ES033800NIH HHS R15ES033800
6 · The paper itself

Abstract

The carcinogenic and mutagenic properties of chromium(VI) complexes have been ascribed to the formation of ternary DNA-Cr(III)-small molecule adducts. However, in no case has a ternary adduct been directly characterized using spectroscopic techniques. As part of these laboratories' efforts to establish the structures and properties of discrete binary and ternary adducts of Cr(III) and DNA at a molecular level, an array of methods has been attempted unsuccessfully to generate ternary DNA-Cr(III)-small molecule adducts with ascorbate, cysteine, glutathione, dithiothreitol, and NADH. These studies along with an analysis of the strength of the interaction between Cr(III) and guanine and the importance of hydrogen bonding in the formation of binary DNA-Cr(III) adducts suggest that ternary DNA-Cr(III)-small molecule adducts may not form under biologically relevant conditions and that the adducts of small molecules and DNA may be solely organic in nature.

Indexed as

ChromiumDNADNA AdductsAscorbic AcidCysteineGlutathioneHydrogen BondingAscorbic AcidChromiumCysteineDNADNA AdductsGlutathioneAscorbateCancerChromiumDNAGlutathioneTernary adducts

Identifiers

PMID40312602
PMCPMC12368977

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.