ArticleNature neuroscience2025
A competitive disinhibitory network for robust optic flow processing in Drosophila.
Article in Nature neuroscience, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
12 citing papers in PubMed.
- Article
- Article
- Centralized brain networks controlling antennal grooming coordination.Nature communications · 2026Article
- Sex-Specific Neuroplasticity in the Brain of a Facultatively Social Orchid Bee.Integrative and comparative biology · 2026Article
- Article
- How tp1, an indirect wing steering muscle, stabilizesbioRxiv : the preprint server for biology · 2025Article
- Article
- A competitive disinhibitory network for robust optic flow processing in Drosophila.Nature neuroscience · 2025Article
- Bilateral interactions of optic-flow sensitive neurons coordinate course control in flies.Nature communications · 2024Article
- Neural mechanisms to incorporate visual counterevidence in self-movement estimation.Current biology : CB · 2023Article
- Multilevel visual motion opponency in Drosophila.Nature neuroscience · 2023Article
- A comprehensive neuroanatomical survey of thebioRxiv : the preprint server for biology · 2023Article
Corrections and comments
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Authors and funding
11 authors.
Funding
Abstract
Many animals navigate using optic flow, detecting rotational image velocity differences between their eyes to adjust direction. Forward locomotion produces strong symmetric translational optic flow that can mask these differences, yet the brain efficiently extracts these binocular asymmetries for course control. In Drosophila melanogaster, monocular horizontal system neurons facilitate detection of binocular asymmetries and contribute to steering. To understand these functions, we reconstructed horizontal system cells' central network using electron microscopy datasets, revealing convergent visual inputs, a recurrent inhibitory middle layer and a divergent output layer projecting to the ventral nerve cord and deeper brain regions. Two-photon imaging, GABA receptor manipulations and modeling, showed that lateral disinhibition reduces the output's translational sensitivity while enhancing its rotational selectivity. Unilateral manipulations confirmed the role of interneurons and descending outputs in steering. These findings establish competitive disinhibition as a key circuit mechanism for detecting rotational motion during translation, supporting navigation in dynamic environments.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.