Evidence map›Paper›PMID 40312341›Full record

ArticleBMC public health2025

Modification of risk for all-cause and cardiovascular disease-related mortality with changes in the body mass index: a prospective cohort study with 12 years follow up.

Yun-Ju Lai, Yung-Feng Yen, Li-Jung Chen, Li-Fei Hsu, Matthew N Ahmadi, Elif Inan-Eroglu, Raaj Kishore Biswas, Po-Wen Ku, Emmanuel Stamatakis

Abstract read
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In one paragraph

Article in BMC public health, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Yun-Ju LaiSchool of Medicine, National Yang Ming Chiao Tung University, Taipei, Taiwan.
Yung-Feng Yen *Department of Health Care Management, National Taipei University of Nursing and Health Sciences, Taipei, Taiwan. yfyen1@gmail.com.
Li-Jung Chen *Department of Exercise Health Science, National Taiwan University of Sport, Taichung, Taiwan.
Li-Fei HsuSection of Infectious Diseases, Taipei City Hospital, Yangming Branch, Taipei, Taiwan.
Matthew N AhmadiCharles Perkins Centre, Faculty of Medicine and Health, University of Sydney, Sydney, NSW, Australia.
Elif Inan-ErogluCharles Perkins Centre, Faculty of Medicine and Health, University of Sydney, Sydney, NSW, Australia.
Raaj Kishore BiswasCharles Perkins Centre, Faculty of Medicine and Health, University of Sydney, Sydney, NSW, Australia.
Po-Wen Ku *Graduate Institute of Sports and Health Management, National Chung Hsing University, Taichung City, Taiwan.
Emmanuel StamatakisCharles Perkins Centre, Faculty of Medicine and Health, University of Sydney, Sydney, NSW, Australia.

Funding

Australian National Health and Medical Research Council Investigator Grant APP1194510Department of Health, Taipei City Government, Taiwan No. 11101-62-042; No. 11201-62-023
6 · The paper itself

Abstract

backgroundThe impact of changes in body mass index (BMI) on the risk of all-cause and cardiovascular disease (CVD)-related mortality has not been extensively studied. We examined whether changes in BMI status over time are associated with risk of all-cause and CVD-related mortality.

methodsThis longitudinal study recruited 90,258 adults between 2002 and 2008 from the Taiwan MJ cohort who underwent repeated BMI measurements at an interval of 3.3 years and were followed up for all-cause and CVD-related mortality over 12.1 years. Cox proportional hazard and Fine-Gray sub-distribution hazard models with death from non-CVD causes as the competing risk was used to determine the impact of changes in BMI status on the risk of all-cause or CVD-related mortality, respectively.

resultsOver 1,094,606 person-years of follow-up, 2,084 participants died, including 391 (18.8%) CVD-related deaths. After adjusting for other covariates, the risks of all cause (adjusted hazard ratio [aHR], 1.86; 95% confidence interval [CI], 1.43-2.43) and CVD-related (aHR, 2.20; 95% CI, 1.24-3.93) mortalities were significantly higher in those with a BMI decrease of > 10% than in those with stable BMI. Participants with obesity at baseline who had BMI increase of > 10% during the follow-up period had a significantly higher risk of all-cause (aHR = 2.30; 95% CI:1.38-3.85) and CVD-related mortality (aHR = 3.44; 95% CI:1.33-8.89).

conclusionsA BMI decrease of > 10% was associated with a high risk of all-cause and CVD-related mortalities. Thus, those experiencing significant BMI decreases should undergo a comprehensive evaluation to mitigate mortality risks.

Indexed as

Body Mass IndexCardiovascular DiseasesAdultAgedCause of DeathFemaleFollow-Up StudiesHumansLongitudinal StudiesMaleMiddle AgedProportional Hazards ModelsProspective StudiesRisk FactorsTaiwanBody mass index changeCardiovascular diseasesCohortMortality

Identifiers

PMID40312341
PMCPMC12044839

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.