Evidence map›Paper›PMID 40312271›Full record

ArticleClinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology2025

Variants of the MRGPRX2 Gene Found in Patients With Hypersensitivity to Quinolones and Vancomycin Show Amplified and Drug-Specific Activation Responses In Vitro.

Paola Leonor Quan, Laia Ollé, Marina Sabaté-Bresco, Elizabeth Guruceaga, José Julio Laguna, Inmaculada Doña, Rosa Muñoz-Cano, José Luis Perez-Gracia, Margarita Martín, Gabriel Gastaminza

Abstract read
In one paragraph

Article in Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
  2. Emerging Therapies for Anaphylaxis.Immunology and allergy clinics of North America · 2026
    Review
  3. Modulation of Mast Cell Activation via MRGPRX2 by Natural Oat Extract.International journal of molecular sciences · 2025
    Article
  4. Article
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Paola Leonor QuanDepartment of Allergy and Clinical Immunology, Clínica Universidad de Navarra [University of Navarra Clinic], Pamplona, Spain.ORCID https://orcid.org/0000-0003-1542-1919
Laia OlléLaboratory of Respiratory Clinical and Experimental Immunoallergy, Institut d'Investigacions Biomèdiques August Pi i Sunyer [August Pi I Sunyer Biomedical Research Institute] (IDIBAPS), Barcelona, Spain.
Marina Sabaté-BrescoDepartment of Allergy and Clinical Immunology, Clínica Universidad de Navarra [University of Navarra Clinic], Pamplona, Spain.ORCID https://orcid.org/0000-0003-2200-0485
Elizabeth GuruceagaInstituto de Investigación Sanitaria de Navarra [Institute for Health Research of Navarra] (IdiSNA), Navarra, Spain.
José Julio LagunaRICORS Red de Enfermedades Inflamatorias [Inflammatory Disease Network], Instituto de Salud Carlos III [National Institute of Health Carlos III], Madrid, Spain.ORCID https://orcid.org/0000-0001-5909-8979
Inmaculada DoñaRICORS Red de Enfermedades Inflamatorias [Inflammatory Disease Network], Instituto de Salud Carlos III [National Institute of Health Carlos III], Madrid, Spain.ORCID https://orcid.org/0000-0002-5309-4878
Rosa Muñoz-CanoRICORS Red de Enfermedades Inflamatorias [Inflammatory Disease Network], Instituto de Salud Carlos III [National Institute of Health Carlos III], Madrid, Spain.
José Luis Perez-GraciaDepartment of Oncology, Clinica Universidad de Navarra, Pamplona, Spain.
Margarita MartínRICORS Red de Enfermedades Inflamatorias [Inflammatory Disease Network], Instituto de Salud Carlos III [National Institute of Health Carlos III], Madrid, Spain.ORCID https://orcid.org/0000-0002-9245-4899
Gabriel GastaminzaDepartment of Allergy and Clinical Immunology, Clínica Universidad de Navarra [University of Navarra Clinic], Pamplona, Spain.

Funding

Fundación de Jesús de Gangoiti y BarreraSpanish Ministry of Science Innovation and Universities and the European Regional Development Fund/European Social Fund "Investing in your future" PID2021-122898OB-100Spanish Ministry of Science Innovation and Universities and the European Regional Development Fund/European Social Fund "Investing in your future" RTI2018-096915-B100
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

cell degranulationdrug hypersensitivityfluoroquinolonesgenetic variantsmast cell receptorsMRGPRX2pseudo‐allergic reactionsvancomycin

Identifiers

PMID40312271
PMCPMC12433733

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.