Evidence map›Paper›PMID 40312256›Full record

ArticleThe journal of prevention of Alzheimer's disease2025

Long-term cumulative physical activity associated with less cognitive decline: Evidence from a 16-year cohort study.

Suhang Song, Meng Hsuan Sung, Diana Diaz, Zhuofan Lin, Allan D Tate, Zhuo Chen, Janani Rajbhandari-Thapa, Grace Bagwell Adams, M Mahmud Khan, Ye Shen and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The journal of prevention of Alzheimer's disease, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Observational
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Suhang SongDepartment of Health Policy and Management, College of Public Health, University of Georgia, Athens, GA, 30602, USA.
Meng Hsuan SungDepartment of Epidemiology and Biostatistics, College of Public Health, University of Georgia, Athens, GA, 30602, USA.
Diana DiazDepartment of Epidemiology and Biostatistics, College of Public Health, University of Georgia, Athens, GA, 30602, USA.
Zhuofan LinDepartment of Global Health, School of Public Health, Peking University, Beijing, 100191, China.
Allan D TateDepartment of Epidemiology and Biostatistics, College of Public Health, University of Georgia, Athens, GA, 30602, USA.
Zhuo ChenDepartment of Health Policy and Management, College of Public Health, University of Georgia, Athens, GA, 30602, USA; School of Economics, Faculty of Humanities and Social Sciences, University of Nottingham Ningbo China, Ningbo, 315100, China.
Janani Rajbhandari-ThapaDepartment of Health Policy and Management, College of Public Health, University of Georgia, Athens, GA, 30602, USA.
Grace Bagwell AdamsDepartment of Health Policy and Management, College of Public Health, University of Georgia, Athens, GA, 30602, USA.
M Mahmud KhanDepartment of Health Policy and Management, College of Public Health, University of Georgia, Athens, GA, 30602, USA.
Ye ShenDepartment of Epidemiology and Biostatistics, College of Public Health, University of Georgia, Athens, GA, 30602, USA.
Lisa M Renzi-HammondInstitute of Gerontology, College of Public Health, University of Georgia, Athens, GA, 30602, USA.
Yinzi JinDepartment of Global Health, School of Public Health, Peking University, Beijing, 100191, China; Institute of Global Health and Development, Peking University, Beijing, 100871, China. Electronic address: yzjin@bjmu.edu.cn.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionPhysical activity (PA) has been reported to delay cognitive decline. However, the role of long-term, cumulative PA (cPA) in cognitive decline remains unclear.

methodsThis longitudinal study obtained data from Health and Retirement Study, 2004-2020. Global cognition was operationalized as the sum of memory and executive function scores on a battery of cognitive tests. cPA was operationalized as the area under the curve of the metabolic equivalent of tasks (MET) adjusted PA. Generalized linear mixed models were fitted to examine the associations between cPA and cognitive change.

resultsThis study included 13,450 cognitively healthy participants, with a mean follow-up duration of 11.06 (SD=4.91) years. Higher cPA was associated with delayed declines in global cognition (p<.001), memory (p<.001) and executive function (p<.001), and such protective benefits grew over the 16-year study period. Longer PA engagement was associated with progressively delayed cognitive decline.

conclusionPA engagement over long timeframes may better maintain cognitive performance.

Indexed as

Cognitive DysfunctionExerciseAgedCognitionCohort StudiesExecutive FunctionFemaleHumansLongitudinal StudiesMaleMemoryMiddle AgedNeuropsychological TestsCognitive declineCumulative physical activityLongitudinal study

Identifiers

PMID40312256
PMCPMC12434247

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.