Evidence map›Paper›PMID 40312052›Full record

ArticleContact dermatitis2025

Terpene Hydroperoxides as Lipid Peroxidation Inducers: Biomimetic and HaCaT Cell Studies in Allergic Contact Dermatitis.

Aaron I Moore, Ana S P Moreira, Tiago Conde, Tânia Melo, Pedro Domingues, Niamh M O'Boyle, M Rosário Domingues

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Contact dermatitis, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Aaron I MooreSchool of Pharmacy and Pharmaceutical Sciences, Trinity Biomedical Sciences Institute, Trinity College Dublin, the University of Dublin, Dublin, Ireland.ORCID https://orcid.org/0000-0001-7443-1792
Ana S P MoreiraCESAM-Centre for Environmental and Marine Studies, Department of Chemistry, University of Aveiro, Campus Universitário de Santiago, Aveiro, Portugal.ORCID https://orcid.org/0000-0003-4745-0984
Tiago CondeCESAM-Centre for Environmental and Marine Studies, Department of Chemistry, University of Aveiro, Campus Universitário de Santiago, Aveiro, Portugal.ORCID https://orcid.org/0000-0002-1125-3885
Tânia MeloCESAM-Centre for Environmental and Marine Studies, Department of Chemistry, University of Aveiro, Campus Universitário de Santiago, Aveiro, Portugal.ORCID https://orcid.org/0000-0002-0508-4034
Pedro DominguesMass Spectrometry Center, LAQV-REQUIMTE, Department of Chemistry, University of Aveiro, Campus Universitário de Santiago, Aveiro, Portugal.ORCID https://orcid.org/0000-0002-8060-7675
Niamh M O'BoyleSchool of Pharmacy and Pharmaceutical Sciences, Trinity Biomedical Sciences Institute, Trinity College Dublin, the University of Dublin, Dublin, Ireland.ORCID https://orcid.org/0000-0001-5660-4944
M Rosário DominguesCESAM-Centre for Environmental and Marine Studies, Department of Chemistry, University of Aveiro, Campus Universitário de Santiago, Aveiro, Portugal.ORCID https://orcid.org/0000-0001-5357-3601

Funding

European Cooperation in Science and TechnologyFundação para a Ciência e a TecnologiaIrish Research Council
6 · The paper itself

Abstract

backgroundTerpene hydroperoxides are oxidation products of fragrance terpenes commonly found in cosmetic and household products. They are moderate to strong contact allergens associated with allergic contact dermatitis (ACD). Through the cleavage of their oxygen-oxygen bond, they have the potential to induce lipid peroxidation (LPO). However, the role of oxidised lipids in the context of ACD is largely unexplored.

objectivesHerein, the capacity of terpene hydroperoxides derived from linalool (Lin-6/7-OOH), geraniol (Ger-6/7-OOH), and limonene (Lim-2-OOH) to induce LPO was evaluated using liposomes in a biomimetic metal-catalysed oxidation system. LPO products were identified and quantified by liquid chromatography-mass spectrometry (LC-MS) and Tandem MS (MS/MS). The C11-BODIPY

resultsLC-MS/MS analysis identified 14 LPO products (long-chain and short-chain) formed under metal-catalysed oxidation mediated by terpene hydroperoxides. All hydroperoxides tested at 50 mM caused significant LPO, with Lim-2-OOH exhibiting exceptionally high oxidising potential. The C11-BODIPY

conclusionsThis work shows the ability of terpene hydroperoxide allergens to cause LPO, raising the possibility that LPO products may act as effectors in the pathogenesis of ACD.

Indexed as

Dermatitis, Allergic ContactHydrogen PeroxideLipid PeroxidationTerpenesAcyclic MonoterpenesBiomimeticsChromatography, LiquidHaCaT CellsHumansKeratinocytesLimoneneOxidation-ReductionTandem Mass SpectrometryAcyclic MonoterpenesgeraniolHydrogen PeroxideLimonenelinaloolTerpenesallergic contact dermatitislipidomicsoxidationphospholipidsterpene hydroperoxides

Identifiers

PMID40312052
PMCPMC12134425

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.