Evidence map›Paper›PMID 40311885›Full record

ArticleBrain, behavior, and immunity2025

Exercise-induced β

Kyle A Smith, Helena Batatinha, Grace M Niemiro, Forrest L Baker, Tiffany M Zúñiga, Douglass M Diak, Preteesh L Mylabathula, Timothy M Kistner, Dan Davini, Emely Hoffman and 5 more

Registry-linked trialAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Brain, behavior, and immunity, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06643221 (Exercise-induced Adrenergic Receptor Signaling as an Immune Adjuvant for Allogeneic Cell Therapies), which is not on this map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06643221 early_phase1recruitingnot on this map

Exercise-induced Adrenergic Receptor Signaling as an Immune Adjuvant for Allogeneic Cell Therapies

TypeinterventionalSponsorUniversity of ArizonaRan2018 to 2031Enrolled200ConditionsLeukemia, Hematopoetic Stem Cell Transplantation, Donor Lymphocyte Infusion, CAR T-Cell TherapyArmsExercise, Isoproterenol, Placebo, Bisoprolol Fumarate Tablet 10 mg, Nadolol (1 x 80 mg) Tablets (Invamed, Inc)
3 · Its place in the literature

Who cites it

13 citing papers in PubMed.

  1. Trial
  2. Review
  3. Review
  4. Article
  5. Exercise and CD8Journal of molecular medicine (Berlin, Germany) · 2026
    Review
  6. Review
  7. Review
  8. Review
  9. Review
  10. Article
  11. Article
  12. Review
  13. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Kyle A SmithSchool of Nutritional Sciences and Wellness, University of Arizona, Tucson, AZ, USA.
Helena BatatinhaSchool of Nutritional Sciences and Wellness, University of Arizona, Tucson, AZ, USA.
Grace M NiemiroSchool of Nutritional Sciences and Wellness, University of Arizona, Tucson, AZ, USA; Department of Pediatrics, University of Arizona, Tucson, AZ, USA.
Forrest L BakerSchool of Nutritional Sciences and Wellness, University of Arizona, Tucson, AZ, USA; Department of Pediatrics, University of Arizona, Tucson, AZ, USA; The University of Arizona Cancer Center, Tucson, AZ, USA.
Tiffany M ZúñigaSchool of Nutritional Sciences and Wellness, University of Arizona, Tucson, AZ, USA.
Douglass M DiakSchool of Nutritional Sciences and Wellness, University of Arizona, Tucson, AZ, USA.
Preteesh L MylabathulaSchool of Nutritional Sciences and Wellness, University of Arizona, Tucson, AZ, USA.
Timothy M KistnerDepartment of Pediatrics, University of Arizona, Tucson, AZ, USA; The University of Arizona Cancer Center, Tucson, AZ, USA.
Dan DaviniDepartment of Pediatrics, University of Arizona, Tucson, AZ, USA.
Emely HoffmanDepartment of Pediatrics, University of Arizona, Tucson, AZ, USA.
Jamie N ColomboDepartment of Pediatrics (Cardiology), University of Arizona, Tucson, AZ, USA.
Michael D SeckelerDepartment of Pediatrics (Cardiology), University of Arizona, Tucson, AZ, USA.
Richard A BondCollege of Pharmacy, Science, and Engineering Research Center, University of Houston, Houston, TX, USA.
Emmanuel KatsanisDepartment of Pediatrics, University of Arizona, Tucson, AZ, USA; The University of Arizona Cancer Center, Tucson, AZ, USA; Department of Immunobiology, University of Arizona, Tucson, AZ, USA; Department of Medicine, University of Arizona, Tucson, AZ, USA; Department of Pathology, University of Arizona, Tucson, AZ, USA.
Richard J SimpsonSchool of Nutritional Sciences and Wellness, University of Arizona, Tucson, AZ, USA; Department of Pediatrics, University of Arizona, Tucson, AZ, USA; The University of Arizona Cancer Center, Tucson, AZ, USA; Department of Immunobiology, University of Arizona, Tucson, AZ, USA. Electronic address: rjsimpson@arizona.edu.

Funding

Exercise as an Immune Adjuvant for Gamma Delta T-cell Therapies in Hematologic MalignanciesR01CA277493 · NCI · UNIVERSITY OF ARIZONA · PI EMMANUEL KATSANIS, Richard J Simpson · 2023 to 2026
$2.5M
T32 Cancer Prevention and Control Training Program Addressing Health DisparitiesT32CA272303 · NCI · UNIVERSITY OF ARIZONA · PI Terry A Badger, Gloria D. Coronado · 2023 to 2026
$1.1M
NCI NIH HHS R01 CA277493NCI NIH HHS T32 CA272303
6 · The paper itself

Abstract

Signaling through the β

Indexed as

ExerciseKiller Cells, NaturalLymphomaReceptors, Adrenergic, beta-2Adrenergic beta-AntagonistsAdultAnimalsFemaleHumansIsoproterenolLymphocytesMaleMiceMice, Inbred C57BLMiddle AgedSignal TransductionAdrenergic beta-AntagonistsIsoproterenolReceptors, Adrenergic, beta-2Adrenergic blockadeAdrenergic signalingCancerExercise immunologyLymphocyte mobilizationPhosphodiesterase inhibition, isoproterenol infusionSingle-cell transcriptomicsTumor progression

Identifiers

PMID40311885
PMCPMC13034990

What OpenQuestion holds

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Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.